Effects of mesenchymal stem cells and their exosomes on the healing of large and refractory macular holes

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Xiaomin ZhangXiaorong Li

Abstract

To assess the efficacy of mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-Exos) to promote the healing of large and refractory macular holes (MHs). Seven patients (age 51-75 years old) with large and long-standing idiopathic MHs underwent vitrectomy, internal limiting membrane peeling, MSC (two patients) or MSC-Exo (five patients) intravitreal injection, and heavy silicon oil, air, 20% SF6, or 14% C3F8 tamponade. The MSCs were isolated from human umbilical cord tissue, and MSC-Exos were isolated from the supernatants of cultured MSCs using sequential ultracentrifugation. Five eyes underwent pars plana vitrectomy (PPV) only, while two underwent PPV combined with cataract surgery. Six MHs were closed, while one remained in a flat-open state. The best-corrected visual acuity (BCVA) was improved in five patients with MH closure and remained unchanged in one patient with MH closure who had a 4-year history of MH. A fibrotic membrane was observed on the surface of the retina in one patient who underwent MSC therapy. One patient who received a higher dose of MSC-Exos exhibited an inflammatory reaction. MSC and MSC-Exo therapy may promote functional and anatomic recovery from MH. MSC-Exo therapy may be a useful and safe met...Continue Reading

References

May 1, 1991·Archives of Ophthalmology·N E Kelly, R T Wendel
May 4, 2007·The British Journal of Ophthalmology·Jost HillenkampHelmut G Sachs
Apr 4, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Zofia MichalewskaJerzy Nawrocki
Jun 15, 2010·Ophthalmology·Zofia MichalewskaJerzy Nawrocki
Oct 26, 2010·American Journal of Ophthalmology·Kenji SudaNagahisa Yoshimura
Nov 19, 2010·Regenerative Medicine·Nanette JoyceJan A Nolta
Feb 8, 2011·Investigative Ophthalmology & Visual Science·Xiaomin ZhangXiaorong Li
Jul 12, 2012·Advanced Drug Delivery Reviews·Ronne Wee Yeh YeoSai Kiang Lim
Feb 20, 2013·Cancer Letters·Mark KatakowskiMichael Chopp
Nov 23, 2013·Investigative Ophthalmology & Visual Science·Anna MachalińskaBogusław Machaliński
Jan 15, 2014·American Journal of Ophthalmology·Yuki MorizaneToshio Okanouchi
Mar 13, 2014·International Journal of Molecular Sciences·Bo YuXiaorong Li
May 30, 2014·International Journal of Molecular Sciences·Yuanfeng JiangXiaorong Li
Nov 27, 2014·Frontiers in Cellular Neuroscience·Hongqi XinMichael Chopp
Sep 5, 2015·Stem Cells Translational Medicine·Thorsten R DoeppnerDirk M Hermann
Sep 24, 2015·Retinal Cases & Brief Reports·Ju Young Kim, Oh Woong Kwon
Nov 17, 2015·Ophthalmic Research·Fernando José De NovelliWalter Yukihiko Takahashi
Mar 16, 2017·The New England Journal of Medicine·Ajay E KuriyanJeffrey L Goldberg
Jul 1, 2017·Scientific Reports·Lingling BaiXiaomin Zhang

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Citations

Jun 26, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Carsten H MeyerMichael J Koss
Aug 9, 2020·Stem Cells International·Jasmin S NurkovićZana Dolićanin
Sep 22, 2020·Advanced Functional Materials·Meadhbh Á BrennanDavid J Mooney
Mar 28, 2019·Frontiers in Neurology·Oh Young Bang, Eun Hee Kim
Jun 20, 2019·International Journal of Molecular Sciences·Hassan MansoorGary Hin-Fai Yam
Aug 18, 2020·Clinical Ophthalmology·Mantapond IttaratPear Pongsachareonnont
Oct 22, 2020·Stem Cells International·Raffaele NuzziAlessandro Vercelli
Jan 18, 2021·Acta Biomaterialia·Vishnu Priya Murali, Christina A Holmes
Mar 15, 2020·Progress in Retinal and Eye Research·Ben Mead, Stanislav Tomarev
Mar 7, 2021·Journal of Clinical Medicine·Byung-Chul LeeKyung-Rok Yu
Mar 13, 2021·Journal of Extracellular Vesicles·Vivian V T NguyenBas W M van Balkom
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Zhengyu ZhangZizhong Hu
Aug 6, 2021·Biologics : Targets & Therapy·Amit Sharma, Bithiah Grace Jaganathan
Sep 28, 2021·Frontiers in Cell and Developmental Biology·Chenyang GuLukui Chen

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