Effects of mesenteric ischemia and reperfusion on small bowel electrical activity

The Journal of Surgical Research
S S HegdeWilliam O Richards

Abstract

Previous studies involving basic electrical rhythm (BER) have not been carried out far enough to fully characterize the relationship between mesenteric ischemia and BER. The phenomenon of reperfusion injury has also not been correlated with BER activity. The goal of this study was to characterize changes in BER during mesenteric ischemia and reperfusion and to correlate them with changes in pathology. Serosal electrodes were used to record the electrical activity of rabbit jejunum (n = 20) at baseline, during ischemia (90-210 min), and during reperfusion (120-240 min). BER frequency and amplitude were monitored, and biopsies were taken at the end of ischemia and reperfusion. A pathologist blinded to the specimen identity graded the histology on a scale of 0 (no changes) to 6 (transmural necrosis). Paired t test, the Kruskal-Wallis test of non-parametric ranks, and Fisher's r to z test were used for statistical significance where appropriate. BER frequency and amplitude fell significantly after 15 min of ischemia and became undetectable by 90 min of ischemia in all animals. The likelihood that BER would return during reperfusion was highly correlated with length of ischemia (r = 0.99). Longer periods of reperfusion were associat...Continue Reading

References

Feb 1, 1968·The American Journal of Digestive Diseases·J Szurszewski, F R Steggerda
Jun 1, 1995·Annals of Surgery·W O RichardsJ P Wikswo
Jun 1, 1994·American Journal of Surgery·J GolzarianW O Richards

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Citations

Aug 22, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L A BradshawW O Richards
Jan 22, 2013·IEEE Transactions on Bio-medical Engineering·Suseela SomarajanWilliam O Richards
Jun 6, 2009·IEEE Transactions on Bio-medical Engineering·Jonathan C EricksonWilliam O Richards
Jul 10, 2003·IEEE Transactions on Bio-medical Engineering·L Alan BradshawWilliam O Richards
Sep 28, 2005·Acta Cirúrgica Brasileira·Nereide Freire CerqueiraWinston Bonetti Yoshida
Nov 26, 2008·Acta Cirúrgica Brasileira·Osvaldo MalafaiaYuki Schneider Aoki
Aug 7, 1999·Journal of Vascular Surgery·S A SeidelW O Richards
Sep 24, 2004·Physiological Measurement·M L BuistA J Pullan
Apr 15, 2006·Digestive Diseases and Sciences·Xiaohong Xu, J D Z Chen
Jun 27, 2006·Annals of Biomedical Engineering·A S LinA J Pullan
Sep 13, 2018·Physiological Measurement·Runar J Strand-AmundsenTor I Tønnessen
May 16, 2018·World Journal of Gastroenterology : WJG·Runar J Strand-AmundsenTor I Tønnessen
May 2, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·S SomarajanW O Richards
Jul 31, 2020·Molecular Therapy. Methods & Clinical Development·Chung-Man MoonSang-Soo Shin
Feb 21, 2019·The Journal of Surgical Research·Suseela SomarajanWilliam O Richards

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