Effects of mesyl salvinorin B alone and in combination with naltrexone on alcohol deprivation effect in male and female mice

Neuroscience Letters
Yan ZhouMary Jeanne Kreek

Abstract

Alcohol relapse plays a major role in alcohol dependence and is an important focus for the treatment of alcoholism. The alcohol deprivation effect (ADE) is a widely used paradigm in rodents to model the relapse episodes that occur in human alcoholics. Mesyl Salvinorin B (MSB) is a potent and selective kappa opioid receptor (KOP-r) full agonist, with fewer side effects (e.g., sedation or anhedonia) than classic KOP-r full agonists and a longer duration of action in mice than the structurally similar salvinorin A. We have recently found that MSB prevents cocaine seeking in a rat self-administration model and reduces excessive alcohol drinking in a mouse escalation model via a KOP-r-mediated mechanism. Here, we further investigated whether MSB alone (0.3-3 mg/kg) or in combination with naltrexone (mu-opioid receptor antagonist at 1 mg/kg) altered alcohol "relapse" drinking using a mouse ADE paradigm. Both male and female mice, exposed to 3-week intermittent access alcohol drinking in a two-bottle choice paradigm with 24-h access every other day, developed excessive alcohol intake and then displayed pronounced ADE after 1-week abstinence. Acute administration of MSB prevented the ADE at 3 mg/kg in both male and female mice. Upon in...Continue Reading

Citations

Feb 27, 2020·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Alaa M Hammad, Youssef Sari
Sep 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdelfattah FaouziSusruta Majumdar
Apr 20, 2018·The Journal of Pharmacology and Experimental Therapeutics·Yan Zhou, Mary Jeanne Kreek
Apr 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elaine C D GonçalvesRafael C Dutra
Jun 24, 2020·Peptides·Richard J Bodnar
Mar 31, 2021·Chemistry : a European Journal·Patrick ZimdarsPeter Metz

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