PMID: 6986917Mar 3, 1980Paper

Effects of metabolic inhibitors on the regulation of pancreatic glucagon release

Biochimica Et Biophysica Acta
C G OstensonA Andersson

Abstract

The effects of metabolic inhibition on the kinetics of glucagon release by pancreatic islets from normal guinea pigs have been studied in a perfusion system. All three metabolic inhibitors, malonate, iodoacetate and 2,4-dinitrophenol, induced a marked stimulation of glucagon secretion, each displaying its own characteristic pattern of response. This was accompanied by a rapid and marked decrease in the ATP concentration of the A2-cell as evidenced by measurements performed in A2-cell rich islets, isolated from guinea pigs treated with streptozotocin. The ATP levels were reduced by about 90% following iodoacetate and 2,4-dinitrophenol exposure and by about 60% after exposure to malonate. The data support the hypothesis that the inhibition of glucagon release from the A2-cell is regulated via an intracellular, energy-dependent mechanism.

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