Effects of Metabolites Produced from (-)-Epigallocatechin Gallate by Rat Intestinal Bacteria on Angiotensin I-Converting Enzyme Activity and Blood Pressure in Spontaneously Hypertensive Rats

Journal of Agricultural and Food Chemistry
Akiko Takagaki, F Nanjo

Abstract

Inhibitory activity of angiotensin I-converting enzyme (ACE) was examined with (-)-epigallocatechin gallate (EGCG) metabolites produced by intestinal bacteria, together with tea catechins. All of the metabolites showed ACE inhibitory activities and the order of IC50 was hydroxyphenyl valeric acids > 5-(3,4,5-trihydroxyphenyl)-γ-valerolactone (1) > trihydroxyphenyl 4-hydroxyvaleric acid ≫ dihydroxyphenyl 4-hydroxyvaleric acid ≫ 5-(3,5-dihydroxyphenyl)-γ-valerolactone (2). Among the catechins, galloylated catechins exhibited stronger ACE inhibitory activity than nongalloylated catechins. Furthermore, the effects of a single oral intake of metabolites 1 and 2 on systolic blood pressure (SBP) were examined with spontaneously hypertensive rats (SHR). Significant decreases in SBP were observed between 2 h after oral administration of 1 (150 mg/kg in SHR) and the control group (p = 0.002) and between 4 h after administration of 2 (200 mg/kg in SHR) and the control group (p = 0.044). These results suggest that the two metabolites have hypotensive effects in vivo.

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Citations

Apr 27, 2016·Journal of Agricultural and Food Chemistry·Yoon Hee KimHirofumi Tachibana
Apr 27, 2016·Pharmacology & Therapeutics·Guanhua DuJuntian Zhang
Mar 28, 2017·Bioscience, Biotechnology, and Biochemistry·Akiko Saito
Dec 25, 2016·Physiological Genomics·Sareema AdnanDavid J Durgan
May 23, 2018·Critical Reviews in Food Science and Nutrition·Arpita Banerjee, Pubali Dhar
Aug 5, 2017·Biological & Pharmaceutical Bulletin·Aya Hara-TerawakiFumio Nanjo
Sep 25, 2019·Nutrients·Estefanía Márquez CamposMarie-Christine Simon
Jul 28, 2019·International Journal of Molecular Sciences·Monira PervinYoriyuki Nakamura
Oct 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guy R AdamiKim Chi Dang
Oct 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xuhuiqun ZhangBritt M Burton-Freeman
Jan 14, 2021·International Journal of Molecular Sciences·Mohammed S M SalehYusof Kamisah
Jul 17, 2021·Frontiers in Nutrition·Maria Carolina Rodríguez-DazaDenis Roy
Oct 10, 2021·Journal of the Science of Food and Agriculture·Ke ZhaoHongfei Wang
Nov 10, 2021·Journal of Food Biochemistry·Chika I ChukwumaOchuko L Erukainure

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