Effects of metformin and alogliptin on body composition in people with type 2 diabetes

Journal of Diabetes Investigation
Yumie TakeshitaToshinari Takamura

Abstract

The aim of the present study was to investigate the effects of metformin and a dipeptidyl peptidase-4 inhibitor, alogliptin, on body composition in a 12-week randomized add-on trial in Japanese participants with type 2 diabetes. A total of 84 participants with poorly controlled type 2 diabetes undergoing antidiabetic therapy were randomly assigned to receive alogliptin (25 mg, once daily) or metformin (1,000 mg, twice daily) for 12 weeks. The primary efficacy end-point was body composition. The secondary end-points included factors associated with decreased bodyweight. Compared with the baseline values, alogliptin significantly increased bodyweight (66.5 ± 19.2 to 67.6 ± 19.3 kg), body mass index (BMI; 25.4 ± 6.1 to 25.8 ± 6.3 kg/m2 ) and fat mass (20.3 ± 12.8 to 21.8 ± 14.5 kg), whereas metformin had no significant effect on body composition. Alogliptin was inferior to metformin in reducing bodyweight (0.84 ± 1.57 vs -0.35 ± 1.53 kg, P = 0.002), BMI (0.34 ± 0.69 to -0.15 ± 0.56 kg/m2 , P = 0.002) and fat mass (1.49 ± 5.06 vs -0.04 ± 1.81 kg, P = 0.042). BMI at baseline was associated with changes in bodyweight negatively in the metformin group and positively in the alogliptin group. Metformin and alogliptin exert opposite effe...Continue Reading

References

Jan 16, 2002·JAMA : the Journal of the American Medical Association·Silvio E Inzucchi
Dec 28, 2004·Nature Medicine·Akira HirasawaGozoh Tsujimoto
Jan 10, 2008·Current Medical Research and Opinion·Avraham KarasikPeter P Stein
Sep 9, 2008·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·John H B Scarpello, Harry C S Howlett
Sep 23, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mariko MorishitaKozo Takayama
Feb 17, 2009·Calcified Tissue International·Bernardo Nuche-BerenguerMaría L Villanueva-Peñacarrillo
Jan 15, 2010·Diabetes, Obesity & Metabolism·P AschnerUNKNOWN Sitagliptin Study 049 Group
Mar 24, 2010·European Journal of Pharmacology·Ying GaoJing Hu
May 21, 2010·Diabetes Care·Diana SherifaliHertzel C Gerstein
May 28, 2011·Journal of Cellular Biochemistry·Qi-Guang MaiXiao-Chun Bai
May 1, 2013·Maturitas·Marianna AntonopoulouAlan S Sacerdote
Jul 6, 2014·PloS One·Antonella NapolitanoDerek J Nunez
Mar 25, 2015·Journal of Diabetes Investigation·Yumie TakeshitaUNKNOWN Establishment of Rationale for Antiaging Diabetic Medicine (ERA-DM) Study Chapter 2 Group
May 15, 2015·Journal of Diabetes Investigation·Akiko TakazakuraToshinari Takamura
Jun 16, 2018·Diabetes Care·Bernard ZinmanUNKNOWN LEADER Publication Committee on behalf of the LEADER Trial Investigators

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Citations

Jul 25, 2019·Expert Opinion on Pharmacotherapy·Jingbo HuYufen Zhao

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Software Mentioned

Statistical Package for the Social Sciences

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