PMID: 1254116Mar 1, 1976Paper

Effects of metformin on insulin resistance after injury in the rat

Diabetologia
K N Frayn

Abstract

Hyperglycaemia and insulin resistance occur after injury. The effects of the antidiabetic biguanide metformin in injured rats have been studied in order to elucidate the cause of these effects. Metformin (120 mg/kg S. C.) produced a significant hypoglycaemic effect after a 20% dorsal scald but did not affect the blood glucose concentration in non-injured rats. The hypoglycaemic effect did not result from increased insulin secretion. It was associated with a reduction in liver glycogen and an increase in blood lactate concentrations, suggesting that the drug acted by promoting peripheral glucose utilization. This was confirmed by measuring the clearance rate coefficient of [5-3H]glucose. This rate coefficient was significantly increased by metformin treatment (140 mg/kg S. C.) in scalded rats, although it was not affected in non-injured rats. Intravenous glucose tolerance in scalded rats was not improved, probably because of the increased lactate concentration. Metformin (120-160 mg/kg) also produced a hypoglycaemic effect in rats after a 4 hrs period of bilateral hind-limb ischaemia, suggesting that similar metabolic changes occur after these two types of injury.

References

Feb 1, 1975·Canadian Journal of Physiology and Pharmacology·I H ChaudryA E Baue
Jul 29, 1975·European Journal of Clinical Investigation·K N Frayn
Oct 1, 1974·The British Journal of Surgery·A E Giddings
Jan 1, 1974·Diabetes·I Polacek, J Ouart
Mar 26, 1968·Annals of the New York Academy of Sciences·R A Altschuld, F A Kruger
Oct 1, 1974·Annals of Surgery·N T RyanR H Egdahl
Aug 1, 1972·Diabetologia·D H SilcockD W Neill
Sep 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M VigasJ Jurcovicová
Dec 1, 1972·Biochemical Pharmacology·K N Frayn, P I Adnitt
Jan 1, 1972·Advances in Experimental Medicine and Biology·D F Heath
Mar 1, 1971·Metabolism: Clinical and Experimental·W J ButterfieldM J Whichelow
Dec 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·E L BeschC E Cornelius
Dec 1, 1971·Postgraduate Medical Journal·K N FraynP Turner
Mar 26, 1968·Annals of the New York Academy of Sciences·B R BoshellG L McAdams
Oct 23, 1970·Deutsche medizinische Wochenschrift·K Irsigler
Jul 1, 1965·The Journal of Physiology·M M AshbyH B Stoner
Jul 1, 1953·The Journal of Endocrinology·M GINSBURG, H HELLER
May 1, 1957·Proceedings of the Society for Experimental Biology and Medicine·G UNGARS L SHAPIRO
Apr 1, 1963·Metabolism: Clinical and Experimental·G M GRODSKYP H FORSHAM
Dec 1, 1961·Klinische Wochenschrift·F H SCHMIDT

Citations

Sep 3, 1981·The New England Journal of Medicine·A HolleH W Rüdiger
Jan 26, 2013·Molecular Medicine·Yaeko HiyamaMarc G Jeschke
Feb 7, 2017·Journal of the American Chemical Society·Bikram Keshari AgrawallaYoung-Tae Chang

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.