Effects of metformin on the expression of GLUT4 in endometrium of obese women with polycystic ovary syndrome

Biology of Reproduction
Jun ZhaiYing-pu Sun

Abstract

The objective was to explore the effects of metformin on the expression of endometrial glucose transporter 4 (GLUT4) and analyze the related factors of GLUT4 in patients with polycystic ovary syndrome (PCOS). This study included 20 obese patients with PCOS (PCOS group) and 20 obese patients who had infertility caused by oviducal or pelvic factors but had no PCOS (control group). Follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol-2 (E(2)), testosterone (T), fasting serum glucose (FSG), fasting insulin serum (FINS), homeostasis model assessment-insulin resistance (HOMA-IR), and endometrial GLUT4 expression were determined in the two groups. In PCOS group, patients were given 500 mg of metformin three times per day for 3 mo, and then the parameters above were determined again and compared with that before metformin treatment. The parameters above also were compared between PCOS and control groups. The correlation of GLUT4 with its related factors was analyzed. The levels of T, FINS, and HOMA-IR were higher in PCOS group than in the control group (P < 0.01). The levels of protein and mRNA of endometrial GLUT4 were lower in the PCOS group than in the control group (P < 0.001). The expression of protein and mRNA ...Continue Reading

References

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Citations

Feb 1, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Gustavo Dias FerreiraEdison Capp
May 13, 2014·Reproductive Biomedicine Online·Stefano PalombaGiovanni Battista La Sala
Feb 12, 2014·Endocrine·Bożenna OleszczakUrszula Stopińska-Głuszak
May 10, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Terhi T Piltonen
Mar 25, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Lan LiKwang-Hyun Baek
Jun 3, 2014·Journal of Experimental & Clinical Cancer Research : CR·Ruijin ShaoHåkan Billig
Jul 6, 2016·Critical Reviews in Oncology/hematology·Angiolo GadducciMartina Gallo
Jun 22, 2017·Human Fertility : Journal of the British Fertility Society·Mariano Mascarenhas, Adam H Balen
Aug 8, 2021·Reproductive Biology and Endocrinology : RB&E·Xuechun BaiYing Xu

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

Pro Analyzer
Gel
SPSS

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