Effects of Metformin Therapy on Coronary Endothelial Dysfunction in Patients With Prediabetes With Stable Angina and Nonobstructive Coronary Artery Stenosis: The CODYCE Multicenter Prospective Study

Diabetes Care
Celestino SarduRaffaele Marfella

Abstract

To evaluate the effect of metformin therapy on coronary endothelial function and major adverse cardiac events (MACE) in patients with prediabetes with stable angina and nonobstructive coronary stenosis (NOCS). Metformin therapy may be needed to reduce coronary heart disease risk in patients with prediabetes. A total of 258 propensity score-matched (PSM) patients with stable angina undergoing coronary angiography were enrolled in the study. Data from 86 PSM subjects with normoglycemia (NG), 86 PSM subjects with prediabetes (pre-DM), and 86 PSM subjects with prediabetes treated with metformin (pre-DM metformin) were analyzed. During coronary angiography, NOCS was categorized by luminal stenosis <40% and fractional flow reserve >0.80. In addition, we assessed the endothelial function, measuring coronary artery diameter of left anterior descending coronary (LAD) at baseline and after the infusion of acetylcholine, by means of an intracoronary Doppler guide wire. MACE, as cardiac death, myocardial infarction, and heart failure, was evaluated at 24 months of follow-up. At baseline, NG patients had a lower percentage of LAD endothelial dysfunction compared with pre-DM patients (P < 0.05). The pre-DM patients had a higher percentage of...Continue Reading

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Citations

Jun 27, 2019·Journal of Diabetes Research·Celestino SarduGaetano Santulli
May 28, 2020·Frontiers in Pharmacology·Mingying DengAizong Shen
Jun 4, 2019·Frontiers in Endocrinology·Gaetano Santulli
Feb 14, 2020·Current Pharmaceutical Design·Celestino SarduRaffaele Marfella
Mar 3, 2020·Experimental and Molecular Pathology·Haochang HuShuangshuang Wang
Dec 31, 2020·Biomedicines·Teresa SalvatoreFerdinando Carlo Sasso
Feb 11, 2021·Pharmaceuticals·Józef Drzewoski, Markolf Hanefeld
Nov 2, 2020·JACC. Cardiovascular Imaging·Celestino SarduRaffaele Marfella
Mar 5, 2020·Journal of the American College of Cardiology·Zoltan UngvariAnna Csiszar
May 1, 2021·International Journal of Molecular Sciences·Yin LiangKen Takahashi
May 1, 2021·International Journal of Molecular Sciences·Diana Jhoseline Medina-LeyteLeonor Jacobo-Albavera
May 29, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Zhiyuan WuLixin Tao
Jun 2, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Edyta SutkowskaAndrzej Gamian Prof
Jun 1, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Ferdinando Carlo SassoLuca Rinaldi
Jun 16, 2021·Nature Reviews. Nephrology·Zoltan UngvariAnna Csiszar
Jun 25, 2021·Frontiers in Immunology·Xiaojun FengJianping Weng
Jul 21, 2021·Current Medical Research and Opinion·Ulrike Hostalek, Ian Campbell

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