Effects of methamphetamine on sexual performance and compulsive sex behavior in male rats.

Psychopharmacology
K S FrohmaderL M Coolen

Abstract

Methamphetamine (Meth) is a highly addictive psychostimulant associated with enhanced sexual desire, arousal, and sexual pleasure. Moreover, Meth abuse is frequently linked with the practice of sexual risk behavior and increased prevalence of human immunodeficiency virus. Currently, there is a lack of studies investigating the effects of Meth on maladaptive sexual behavior under controlled experimental settings in animal studies. The overall objective of the current study was to examine the effects of Meth on various aspects of male sexual behavior including maladaptive sex-seeking behavior. First, a dose-response curve of the effects of Meth (0, 1, 2, and 4 mg/kg; s.c.) on sexual motivation and performance was conducted in sexually naïve and experienced male rats. Next, the effects of Meth (1 mg/kg; s.c.) on inhibition of maladaptive sexual behavior was tested using a sex aversion conditioning paradigm, in which visceral illness induced by lithium chloride (LiCl) was paired with sexual behavior. Meth administration inhibited sexual performance in a dose-dependent matter as evidenced by the decreased percentages of males that mated and increased latencies to initiate sexual behavior when injected with 2 or 4 mg/kg Meth. Moreove...Continue Reading

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Citations

Dec 26, 2013·Pharmacology, Biochemistry, and Behavior·J G Veening, L M Coolen
Jul 7, 2015·The Journal of Sexual Medicine·Nan-Hua ChouBang-Ping Jiann
Jan 5, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lindsey B KuiperLique M Coolen
Oct 20, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lindsey B KuiperLique M Coolen
Jan 14, 2020·Physiological Research·L MihalčíkováR Šlamberová

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