Effects of Methanolic Extract Based-Gel From Saudi Pomegranate Peels With Enhanced Healing Potential on Excision Wounds in Diabetic Rats.

Frontiers in Pharmacology
Shahid KarimMohammad Imran Khan

Abstract

Introduction: Current study was designed to evaluate the wound healing activity of a Saudi pomegranate peel extract on excision wound healing in experimentally induced diabetes in rats. Methodology: Animals were divided into three groups: diabetic excision wound with no treatment, diabetic excision wound with gel alone and diabetic excision wound with Saudi pomegranate peel extract in gel. Animals were monitored for clinical signs, weekly body weight, morbidity and mortality during entire study period. The efficacy parameters evaluated were percent wound contraction, Hydroxyproline content, estimation of Transforming Growth Factor ß1 (TGF-ß1), Vascular Endothelial Growth Factor (VEGF), and Epidermal Growth Factor (EGF) in wound lysates by ELISA, mRNA expression of TGF-ß1, VEGF, and EGF in wound lysates by qPCR, Estimation of nitric oxide (NO) and NO synthase (NOS) in Wound Lysates and histopathology of skin for reepithelization, neovascularization, and inflammation. Results: The Saudi pomegranate peel extract in gel (5.0 g extract per 100 g gel) showed significant wound healing activity when compared to the vehicle control [p < 0.05] following 21 days of treatment. Animals in the control and treatment groups were apparently nor...Continue Reading

References

Dec 16, 1998·British Journal of Plastic Surgery·G E SpyrouI L Naylor
Jan 9, 2001·The Journal of Investigative Dermatology. Symposium Proceedings·M G TonnesenR A Clark
Apr 27, 2002·American Journal of Surgery·Maria B Witte, Adrian Barbul
Jul 26, 2003·The Journal of Investigative Dermatology·Pierre A Coulombe
Aug 10, 2004·Journal of Medicinal Food·K N Chidambara MurthyUma D Murthy
Feb 18, 2005·Acta Pharmacologica Sinica·Jian-dong Luo, Alex F Chen
Dec 13, 2006·Journal of Ethnopharmacology·Ephraim P Lansky, Robert A Newman
May 4, 2007·The Journal of Clinical Investigation·Harold Brem, Marjana Tomic-Canic
May 16, 2008·Nature·Geoffrey C GurtnerMichael T Longaker
Jan 9, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Stephan BarrientosMarjana Tomic-Canic
Aug 27, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jie NiOlivier Devuyst
Jan 16, 2010·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Joseph V Boykin
Apr 7, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E A HayouniM Hamdi
May 31, 2012·International Journal of Pharmaceutics·Hnin-Ei ThuShiow-Fern Ng
Nov 1, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Denso HayashiMasahiro Tachi
Apr 23, 2013·Life Sciences·Paulo Zoé Costa, Raquel Soares
Dec 3, 2014·The Journal of Surgical Research·Vinay KantDinesh Kumar
Dec 23, 2014·Food Chemistry·Saeed AkhtarPiero Sestili
Jun 18, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gaofeng YuanHaiyan Sun
Mar 13, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Richard J BodnarAlan Wells
May 18, 2016·Cellular and Molecular Life Sciences : CMLS·Ning Xu LandénMona Ståhle
Aug 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aline FleckThelma B Machado
Jan 22, 2017·Advances in Therapy·George Han, Roger Ceilley
Feb 1, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jie ZhouZhiguo Zheng
Apr 20, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Katyakyini MuniandyPalanisamy Arulselvan
Jun 9, 2018·Frontiers in Pharmacology·Dongdong WangAtanas G Atanasov
Sep 7, 2018·Frontiers in Pharmacology·Yaw D BoakyeKwabena O Danquah
Jan 19, 2019·BMC Complementary and Alternative Medicine·Woan Sean TanSharida Fakurazi
May 28, 2019·International Journal of Biological Macromolecules·Tamer I M RagabMohamed A El Raey
Apr 22, 2020·Critical Reviews in Food Science and Nutrition·Maryam PirzadehMohammad S Mubarak
Apr 24, 2020·PloS One·Uzoagu A OkonkwoLuisa A DiPietro
Oct 3, 2020·Annals of Saudi Medicine·Shadi AlshammaryHanan M Alghamdi
Oct 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tandokazi Pamela MaganganaUmezuruike Linus Opara

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Aug 23, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Omid YazarluMaede Hasanpour

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