PMID: 15329477Aug 27, 2004Paper

Effects of methoxychlor exposure during perinatal period on reproductive function after maturation in rats

The Journal of Reproduction and Development
Masatoshi SuzukiMasugi Nishihara

Abstract

Methoxychlor (MXC) is a non-steroidal pesticide that is known to possess estrogenic activity, and therefore may be potentially hazardous to the development and/or reproduction. The present study assessed the effects of perinatal exposure to MXC on reproductive function after maturation in both male and female rats. Pregnant rats were fed a phytoestrogen-free diet containing different doses of MXC (24, 240, and 1200 ppm) from day 15 of gestation to day 10 after parturition, and reproductive functions of offspring were examined after maturation. In males, MXC exposure during the perinatal period decreased serum LH and FSH, but not testosterone levels, but it did not affect copulatory behavior. In females, MXC exposure prolonged the days exhibiting cornified vaginal smears during the estrous cycle. In addition, both the lordosis reflex and preovulatory LH surge on the presumptive proestrous evening were suppressed in MXC-exposed females. These results suggest that perinatal exposure to MXC exerts permanent effects on several aspects of the reproductive function in both male and female rats.

References

Dec 1, 1977·Hormones and Behavior·B S McEwenL C Krey
Jan 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·L E GrayJ Laskey
Nov 1, 1970·Journal of Agricultural and Food Chemistry·I P KapoorG K Sangha
Mar 20, 1981·Science·N J MacLusky, F Naftolin
Jul 1, 1995·Reproductive Toxicology·V P EroschenkoM S Grober
Oct 1, 1993·Environmental Health Perspectives·T ColbornA M Soto
Oct 1, 1995·Environmental Health Perspectives·A M SotoF O Serrano
Jul 1, 1997·Critical Reviews in Toxicology·A M Cummings
Mar 10, 1998·Proceedings of the Society for Experimental Biology and Medicine·A A FrankeC Y Shi
Nov 24, 1999·Reproductive Toxicology·S Y AmstislavskyV P Eroschenko
Dec 2, 1999·Neuroscience and Biobehavioral Reviews·P PalanzaF S vom Saal
Feb 5, 2002·Molecular Genetics and Metabolism·Masatoshi Suzuki, Masugi Nishiahara
Nov 19, 2002·Neuroscience Letters·Keisuke YoneharaMasugi Nishihara

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Citations

Sep 2, 2009·The Journal of Reproduction and Development·Masatoshi SuzukiMasugi Nishihara
Mar 29, 2007·The Journal of Reproduction and Development·Yuling MiKazuyoshi Taya
Mar 5, 2013·Toxicology and Applied Pharmacology·Bachir Abi SalloumVasantha Padmanabhan
Mar 20, 2008·Fertility and Sterility·Hugh S Taylor
Nov 22, 2007·Ecotoxicology and Environmental Safety·Saumen Kumar Maitra, Anindita Mitra
Feb 10, 2006·Annals of the New York Academy of Sciences·Michael K Skinner, Matthew D Anway
Aug 26, 2014·Reproductive Toxicology·Agnes StefansdottirNorah Spears
Jan 30, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A LafuenteA I Esquifino
Jul 6, 2011·Neurotoxicology·Jennifer BertolasioAline M Davis
Oct 16, 2007·Journal of Physiology and Biochemistry·A LafuenteA I Esquifino

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