Effects of methyl mercury on the in vivo release of dopamine and its acidic metabolites DOPAC and HVA from striatum of rats

Ecotoxicology and Environmental Safety
L R FaroC W Picanço-Diniz

Abstract

Mercury is a neurotoxic agent that produces different effects on the brain. In the present work, the effects of chronic doses of methyl mercury (MeHg) were studied on the dopaminergic system of the rat striatum, using microdialysis coupled to high-performance liquid chromatography in order to quantify the in vivo release of dopamine (DA) and its acidic metabolites DOPAC and HVA. The administration of an equivalent total dose of 6 mg/kg of MeHg induced significant increases in the striatal release of DA and/or its acidic metabolites, independently of the pattern of administration. These effects are discussed on the base of the release and the metabolization of DA. In conclusion, the effect of MeHg administered under these experimental conditions on the in vivo release of DA and its metabolites seems to have a dose-dependent component and seems to be an accumulative process.

Citations

Jan 31, 2012·Journal of Toxicology·Sanah SadiqDietrich Büsselberg
Nov 1, 2002·Brain Pathology·William O Whetsell
Jul 19, 2021·Neurotoxicology and Teratology·Dalisa R Kendricks, M Christopher Newland
Jan 30, 2008·Neurotoxicology and Teratology·Donnie EddinsEdward D Levin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.