PMID: 6405723Feb 1, 1983Paper

Effects of methyl methacrylate on non-protein thiols and drug metabolizing enzymes in rat liver and kidneys

Archives of Toxicology
E ElovaaraH Vainio

Abstract

Male Wistar rats received methyl methacrylate monomer (MMA) i.p. in olive oil 1.0 g/kg body weight on 3 successive days. The weight of the livers and kidneys, and the body weights did not differ from their controls. On the fifth day after treatment, hepatic NADPH-cytochrome c reductase, 7-ethoxycoumarin 0-deethylase and the 2,5-diphenyloxazole hydroxylase exhibited maximal decreases in activity (25%, 58%, 36%, respectively) without any coincident effect on the total amount of cytochrome P-450 hemoprotein itself. One week later these activities had returned to control levels. The enzymatic changes in the kidneys were smaller in magnitude, and they were also reversed sooner. A single i.p. dose of MMA (2 g/kg body weight) caused elevation of serum alanine aminotransferase activity. A tenfold increase of the excretion rate of urinary thioethers was also discovered. The hepatic reduced glutathione (GSH) was depleted in 3 h to 20% and the GSSG to half of the value in controls. In kidneys, the GSH was decreased to 48% in 3 h before an apparent phase of overrecovery. At the end of the 24 h observation period, cytochrome P-450 concentrations were somewhat decreased in the liver. The GSH contents showed dose and time-dependent reversible...Continue Reading

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Citations

Jul 1, 1984·Archives of Toxicology·S VainiotaloH Savolainen
Aug 9, 2001·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A FreidigJ Hermens
Dec 21, 2010·Journal of Biomedical Materials Research. Part a·J T SamuelsenJ E Dahl
Mar 16, 2011·Critical Reviews in Toxicology·Jonathan BorakMark A Pemberton
Nov 24, 2004·Journal of Dental Research·M LefeuvreL Stanislawski
May 31, 2001·Journal of Dental Research·J EngelmannW Geurtsen
Oct 27, 2018·Brazilian Oral Research·Luciano Tavares Angelo CintraJoão Eduardo Gomes-Filho

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