Effects of methylmercury and retinol palmitate co-administration in rats during pregnancy and breastfeeding: Metabolic and redox parameters in dams and their offspring

Ecotoxicology and Environmental Safety
Pedro Espitia-PérezJosé Cláudio Fonseca Moreira

Abstract

Ubiquitous low-dose methylmercury (MeHg) exposure through an increased fish consumption represents a global public health problem, especially among pregnant women. A plethora of micronutrients presented in fish affects MeHg uptake/distribution, but limited data is available. Vitamin A (VitA), another fish micronutrient is used in nutritional supplementation, especially during pregnancy. However, there is no information about the health effects arising from their combined exposure. Therefore, the present study aimed to examine the effects of both MeHg and retinyl palmitate administered on pregnant and lactating rats in metabolic and redox parameters from dams and their offspring. Thirty Wistar female rats were orally supplemented with MeHg (0,5 mg/kg/day) and retinyl palmitate (7500 µg RAE/kg/day) via gavage, either individually or in combination from the gestational day 0 to weaning. For dams (150 days old) and their offspring (31 days old), glycogen accumulation (hepatic and cardiac) and retinoid contents (plasma and liver) were analyzed. Hg deposition in liver tissue was quantified. Redox parameters (liver, kidney, and heart) were evaluated for both animals. Cytogenetic damage was analyzed with micronucleus test. Our results ...Continue Reading

Citations

Dec 7, 2019·Chemosphere·Helen Tais da Rosa-SilvaJosé Cláudio Fonseca Moreira
Feb 3, 2020·Chemico-biological Interactions·Blessing A AfolabiAna Lúcia Anversa Segatto
Nov 18, 2020·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Helen Tais da Rosa-SilvaJosé Cláudio Fonseca Moreira

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