PMID: 9161888Jul 1, 1997Paper

Effects of methylphenidate in children with attention deficit hyperactivity disorder: a comparison of event-related potentials between medication responders and non-responders

International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology
G A SunoharaM J Taylor

Abstract

Event-related potentials (ERPs) were compared among three groups, each with 13 subjects: (1) ADHD non-responders to methylphenidate treatment; (2) ADHD responders to methylphenidate treatment; and (3) normal control children. Response to methylphenidate was determined through extensive psychoeducational and cognitive assessments during a 4-week double-blind medication assessment. ERPs were recorded each week from 13 active electrodes during a visual feature detection task and a semantic classification task. Significant group effects were found for N2 and P3b latencies due to longer latencies for the ADHD children. Off medication, there were no differences between responders and non-responders. However, on methylphenidate non-responders had significantly longer P3b latencies than responders. Cognitive testing also revealed differential performance on medication between non-responders and responders on the paired-associate learning (PAL) task. Thus, both cognitive and ERP measures were found to differentiate ADHD non-responders and responders to methylphenidate treatment.

References

Jan 1, 1976·Journal of Abnormal Child Psychology·R A Barkley
Jan 1, 1975·Journal of Abnormal Child Psychology·J S WerryM N Cohen
Sep 1, 1987·Journal of the American Academy of Child and Adolescent Psychiatry·A J Zametkin, J L Rapoport
Nov 21, 1974·The New England Journal of Medicine·J M Krager, D J Safer
Jul 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·R TannockR Schachar
Aug 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·J K BuitelaarM Kuiper
Nov 1, 1993·Electroencephalography and Clinical Neurophysiology·M J Taylor
Oct 1, 1994·Journal of Abnormal Child Psychology·M N VerbatenH van Engeland
Jul 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·M Semrud-ClikemanK Bekken
Jul 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·G J DuPaulM B McMurray

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Citations

Jun 7, 2005·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Daniel F HermensEvian Gordon
Jun 1, 2005·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Samantha J BroydCarlie A Lawrence
Aug 23, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·K E ZillessenA Warnke
Feb 1, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Robert J BarryAdam R Clarke
Mar 23, 2011·Neuropsychologia·Päivi HeleniusMarkku Niemivirta
Dec 5, 2000·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·K HennighausenH Remschmidt
May 1, 2001·The International Journal of Neuroscience·I LazzaroS Clarke

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