PMID: 9539412Apr 16, 1998Paper

Effects of metrifonate on cognitive decline in Alzheimer disease: a double-blind, placebo-controlled, 6-month study

Alzheimer Disease and Associated Disorders
R E BeckerS Vicari

Abstract

Forty-seven patients with probable Alzheimer disease (AD) completed a 6-month double-blind study to compare metrifonate with placebo. The Alzheimer Disease Assessment Scale cognitive subscale score of the metrifonate group treated to a 50-70% inhibition of red blood cell acetylcholinesterase activity differed significantly from the placebo group score by 1.8 points (p < 0.03) due to a deterioration in cognitive performance in the placebo group (p < 0.01). Statistically significant deterioration also occurred in the Mini-Mental State Examination scores (p < 0.01) in the placebo-treated group. Adverse effects were uncommon and did not require adjustment of the dose of metrifonate or discontinuation of treatment. These findings extend our previous report of a favorable effect of metrifonate on cognitive symptoms in AD by showing clinical, not only statistical, significance.

Citations

Jun 16, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cindy K J LiebenRudy Schreiber
Jan 15, 2009·Journal of Clinical Psychopharmacology·Robert E Becker, Nigel H Greig
Aug 14, 1999·Journal of Geriatric Psychiatry and Neurology·C Donaldson, A Burns
Dec 29, 2000·Journal of Geriatric Psychiatry and Neurology·L DemersC Wolfson
Apr 21, 2006·The Cochrane Database of Systematic Reviews·J M López-Arrieta, L Schneider
May 31, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Jun WangLan Tan
Nov 30, 2000·Current Treatment Options in Neurology·A S Schachter, K L Davis
Dec 16, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Robert E BeckerNigel H Greig
Nov 22, 2005·Mechanisms of Ageing and Development·Alessia LanariLucilla Parnetti

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