Effects of metrifonate on radial arm maze acquisition in middle-aged rats

Brain Research
S DachirA Levy

Abstract

The efficacy of metrifonate, a well-tolerated cholinesterase (ChE) inhibitor, in attenuating the normal aging- and corticosterone-induced impairments of radial maze performance of rats was compared. Middle-aged Fischer 344 rats were screened for their spatial orientation performance in the Morris water escape task. Good and bad performers were selected: good performers (N= 22) were treated with subcutaneous sustained-release corticosterone pellets, resulting in hippocampal cell damage and impaired spatial orientation in the radial maze; age-induced bad performers (N = 20) were tested without additional pharmacological intervention. Metrifonate (MFT), administered daily during radial maze testing, 30 min before training, at a dose of 15 mg/kg p.o., facilitated the acquisition of the task in age-impaired rats, but not in corticosterone-impaired rats.

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Citations

May 28, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Pascale C BougerFranz-Josef van der Staay
Oct 8, 1999·European Journal of Pharmacology·J PrickaertsA Blokland
Apr 20, 2001·Neurochemistry International·Z Rakonczay, H Papp
Jun 16, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cindy K J LiebenRudy Schreiber
Mar 17, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Erin Y Sterner, Lisa E Kalynchuk
Nov 26, 2008·Neurotoxicology and Teratology·Raymond F GenoveseE Michael Jakubowski
Feb 7, 2006·Journal of Physiology, Paris·John F Disterhoft, M Matthew Oh

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