PMID: 1521669Apr 1, 1992

Effects of mexiletine on the haemodynamic responses to tracheal intubation

The Journal of International Medical Research
K MikawaH Obara


The efficacy of intravenous mexiletine in attenuating the cardiovascular responses to laryngoscopy and tracheal intubation was studied in 30 normotensive patients undergoing elective surgery. The patients were randomly allocated to one of three treatment groups: saline (n = 10); 2 mg/kg mexiletine (n = 10); and 3 mg/kg mexiletine (n = 10). The placebo/mexiletine was administered immediately before induction of anaesthesia using 5 mg/kg thiopentone and tracheal intubation was facilitated with 0.2 mg/kg vecuronium; laryngoscopy lasting 30 s was attempted 2 min after induction of anaesthesia. All groups showed a significant (P less than 0.05) increase in mean arterial pressure and heart rate associated with tracheal intubation. The increase in mean arterial pressure was significantly (P less than 0.05) smaller in patients receiving 3 mg/kg mexiletine compared with those receiving either saline or 2 mg/kg mexiletine. There was no significant attenuation in heart rate in either of the mexiletine treatment groups compared with the saline group. It is concluded that 3 mg/kg mexiletine given intravenously provides a simple and effective method for attenuating the pressor response to laryngoscopy and tracheal intubation.


Oct 1, 1991·British Journal of Anaesthesia·K MikawaH Obara
Jan 1, 1991·The Journal of International Medical Research·K MikawaM Kusunoki
Nov 1, 1990·Journal of Clinical Anesthesia·K MikawaH Obara
Feb 1, 1990·British Journal of Anaesthesia·K MikawaM Kusunoki

Related Concepts

Diastolic Blood Pressure
Intubation, Intratracheal
Pulse Rate
Laryngoscopic Surgical Procedures

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