PMID: 6965403Jan 1, 1980Paper

Effects of microlesions of dorsal cap of inferior olive of rabbits on optokinetic and vestibuloocular reflexes

Journal of Neurophysiology
N H Barmack, J I Simpson

Abstract

1. Discrete, unilateral, electrolytic lesions of the dorsal cap of the inferior olive were made in rabbits in an attempt to assess the effect on eye movements of removal of a visual climbing fiber input to the fluocculus. The position of the lesioning electrode within the dorsal cap was adjusted on the basis of the field potential evoked by flash stimulation of the contralateral eye. 2. Electrophysiological and anatomical evidence confirmed that the microlesions of the dorsal cap destroyed 10-80% of olivary cells, but cause only slight damage to the olivocerebellar pathway originating from the contralateral dorsal cap. 3. The immediate effect of the microlesions was a spontaneous, conjugate drift of the eyes to the side contralateral to the lesion. The effects of the microlesions on eye movements were further examined using reflexes evoked by vestibular and optokinetic stimulation. 4. Postoperatively, the vestibuloocular reflex (VOR) gain was not modified, but there was a marked VOR velocity bias to the contralateral side. This velocity bias was most pronounced at low stimulus frequencies (0.02-0.05 Hz, +/- 10 degrees) and was minimal at stimulus frequencies above 0.5 Hz. 5. Monocular, sinusoidal optokinetic stimulation with a ...Continue Reading

Citations

Mar 27, 2001·The European Journal of Neuroscience·R WehrléI Dusart
Aug 6, 2005·Experimental Brain Research·Troy L Carter, James G McElligott
Aug 1, 1986·Italian Journal of Neurological Sciences·D NutiA Federico
Aug 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Xiang WuKhalaf O Bushara
Dec 20, 1981·The Journal of Comparative Neurology·N MontgomeryL Bengston
Nov 21, 1998·The European Journal of Neuroscience·J P Welsh, J A Harvey
Jan 1, 1983·Acta Oto-laryngologica. Supplementum·T MatsunagaT Kubo
Jul 18, 2008·Journal of Neurophysiology·T LiuK Bushara
Feb 8, 1993·The Journal of Comparative Neurology·N H BarmackP Errico
Aug 1, 1982·The Journal of Comparative Neurology·G Holstege, H Collewijn
May 24, 1996·Science·J L RaymondM D Mauk

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