Effects of micronutrients on DNA repair.

European Journal of Nutrition
Andrew R CollinsSabine A S Langie

Abstract

DNA repair is an essential cellular function, which, by removing DNA damage before it can cause mutations, contributes crucially to the prevention of cancer. Interest in the influence of micronutrients on DNA repair activity is prompted by the possibility that the protective effects of fruits and vegetables might thus be explained. Two approaches to measuring repair-monitoring cellular removal of DNA damage and incubating cell extract with specifically damaged DNA in an in vitro assay-have been applied in cell culture, whole animal studies, and human trials. In addition, there are numerous investigations at the level of expression of DNA repair-related genes. Depending on the pathway studied and the phytochemical or food tested, there are varied reports of stimulation, inhibition or no effect on DNA repair. The clearest findings are from human supplementation trials in which lymphocytes are assessed for their repair capacity ex vivo. Studying cellular repair of strand breaks is complicated by the fact that lymphocytes appear to repair them very slowly. Applying the in vitro repair assay to human lymphocytes has revealed stimulatory effects on repair of oxidised bases by various micronutrients or a fruit- and vegetable-rich diet...Continue Reading

References

Oct 1, 1989·The Journal of Nutrition·S M HenningM E Swendseid
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M Klaude, A von der Decken
Feb 1, 1997·Biochemical Society Transactions·A R CollinsS G Wood
Jul 23, 1998·Cancer Detection and Prevention·Y ShengJ Hua
Sep 16, 1998·International Journal of Radiation Biology·E M Taylor, A R Lehmann
Aug 5, 2000·Free Radical Biology & Medicine·R M ElliottD B Archer
May 18, 2001·Biochemical Society Transactions·A R Collins, E Horváthová
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M TomasettiA R Collins
Aug 11, 2001·Science·P A Jones, D Takai
Jan 10, 2002·Genes & Development·Adrian Bird
Mar 9, 2002·Toxicology and Applied Pharmacology·Michael GleiBeatrice Louise Pool-Zobel
Mar 29, 2003·Carcinogenesis·Andrew R CollinsRachel Melvin
Nov 10, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Catherine M GedikUNKNOWN ESCODD (European Standards Committee on Oxidative DNA Damage)
Nov 13, 2004·Annals of Internal Medicine·Edgar R MillerEliseo Guallar
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ming Zhu FangChung S Yang
Jul 18, 2006·Free Radical Biology & Medicine·Peter Møller, Steffen Loft
Mar 1, 2007·JAMA : the Journal of the American Medical Association·Goran BjelakovicChristian Gluud
Mar 17, 2007·Critical Reviews in Food Science and Nutrition·Eun-Sun Hwang, Phyllis E Bowen
Apr 21, 2007·The British Journal of Nutrition·Simonetta GuarreraGiuseppe Matullo
Sep 13, 2007·Nature Reviews. Molecular Cell Biology·Benoît D'Autréaux, Michel B Toledano
Oct 11, 2007·The British Journal of Nutrition·Serena GuarnieriPeter Møller
Jun 3, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ines BouhlelLeila Chekir-Ghedira
Aug 13, 2008·Brain Research·Tetyana V BagnyukovaIgor P Pogribny
Sep 25, 2008·Lab on a Chip·J-F MillauS Sauvaigo
Feb 28, 2009·Free Radical Biology & Medicine·Nasser H ZawiaFernando Cardozo-Pelaez

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Citations

Feb 23, 2013·Drug Design, Development and Therapy·Wael M El-Sayed, Warda A Hussin
Aug 13, 2014·Drug Design, Development and Therapy·Warda A HussinWael M El-Sayed
Mar 13, 2014·Journal of Applied Genetics·Karolina SłoczyńskaAnna M Waszkielewicz
Sep 30, 2014·Biological Trace Element Research·Gisel PadulaAnalía I Seoane
Sep 18, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·S A S LangieJ C Mathers
Apr 3, 2012·Mutation Research·Amaya Azqueta, Andrew R Collins
Sep 1, 2015·Frontiers in Genetics·Sabine A S LangieAndrew R Collins
Jun 25, 2015·Carcinogenesis·Sabine A S LangieAndrew R Collins
Jun 23, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Alexandra HudecováMária Dušinská
Sep 10, 2014·Frontiers in Genetics·Amaya AzquetaAndrew Collins
Oct 3, 2012·Clinical Epigenetics·Olivier J SwitzenyAlexander G Haslberger
Aug 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marius Alexandru MogaLiana Ples
Apr 23, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sabine A S LangieJohn C Mathers
Apr 8, 2020·International Journal of Molecular Sciences·Pavel VodickaLudmila Vodickova
Jan 24, 2019·World Journal of Gastroenterology : WJG·Carolina Vieira De AlmeidaAmedeo Amedei
Sep 22, 2018·Deutsches Ärzteblatt International·Gundula BehrensUte Mons
Aug 26, 2021·Environmental Science and Pollution Research International·Sumira MalikVinay Kumar

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