Effects of micronutrients on metal toxicity

Environmental Health Perspectives
M A PerazaL T Rael

Abstract

There is growing evidence that micronutrient intake has a significant effect on the toxicity and carcinogenesis caused by various chemicals. This paper examines the effect of micronutrient status on the toxicity of four nonessential metals: cadmium, lead, mercury, and arsenic. Unfortunately, few studies have directly examined the effect of dietary deficiency or supplementation on metal toxicity. More commonly, the effect of dietary alteration must be deduced from the results of mechanistic studies. We have chosen to separate the effect of micronutrients on toxic metals into three classes: interaction between essential micronutrients and toxic metals during uptake, binding, and excretion; influence of micronutrients on the metabolism of toxic metals; and effect of micronutrients on secondary toxic effects of metals. Based on data from mechanistic studies, the ability of micronutrients to modulate the toxicity of metals is indisputable. Micronutrients interact with toxic metals at several points in the body: absorption and excretion of toxic metals; transport of metals in the body; binding to target proteins; metabolism and sequestration of toxic metals; and finally, in secondary mechanisms of toxicity such as oxidative stress. T...Continue Reading

References

May 1, 1977·The Journal of Nutrition·P Washko, R J Cousins
Feb 1, 1977·Environmental Research·S Jugo
Aug 1, 1977·Environmental Health Perspectives·O A Levander
Aug 1, 1978·Environmental Health Perspectives·S Skerfving
Feb 1, 1979·Environmental Health Perspectives·R J Cousins
Oct 1, 1979·Archives of Dermatology·S L WagnerR S Braman
Apr 1, 1979·Environmental Health Perspectives·M R Fox
Nov 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·J C Barton, M E Conrad
Nov 1, 1978·American Journal of Epidemiology·J M HarringtonJ Housworth
May 1, 1977·Toxicology and Applied Pharmacology·D Kello, K Kostial
Aug 1, 1977·Environmental Health Perspectives·V H Ferm
Jul 1, 1977·Journal of Comparative Pathology·J N MorrisonW R Humphries
Nov 1, 1976·The Science of the Total Environment·D Barltrop, H E Khoo
Oct 1, 1976·Pharmacology, Biochemistry, and Behavior·E D BiglerD E Shearer
Aug 4, 1975·Biochemical and Biophysical Research Communications·M G Cherian, Z A Shaikh
May 1, 1992·Journal of Clinical Epidemiology·J L ValentineP A Lachenbruch
Feb 15, 1991·Biochemical Pharmacology·J P Bressler, G W Goldstein
Jan 1, 1990·Comparative Biochemistry and Physiology. A, Comparative Physiology·M J RichardN L Jacobson
Feb 1, 1991·Environmental Health Perspectives·J G PoundsJ F Rosen
Nov 1, 1990·Environmental Health Perspectives·G W Goldstein
Feb 1, 1987·Journal of Neurochemistry·T J Simons, G Pocock
Apr 1, 1989·Biological Trace Element Research·R J Kraus, H E Ganther
Jan 1, 1989·Journal of Biochemical Toxicology·A AlboresJ W Bridges
Jan 1, 1987·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A E FunkF O Brady
Jan 1, 1988·Archives of Toxicology·L Szinicz, W Forth
Oct 1, 1986·British Medical Bulletin·T J Simons
May 1, 1987·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·W VicteryR A Goyer
Feb 1, 1974·Archives of Environmental Health·R A Shakman
Aug 1, 1969·The Biochemical Journal·S M Snaith, G A Levvy

❮ Previous
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Citations

Jan 31, 2014·Indian Journal of Clinical Biochemistry : IJCB·Manish K SinghSanjay Khattri
Feb 25, 2014·International Journal of Biological Macromolecules·Leilei LiXiaojiao Wang
Apr 20, 2014·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Kevin M RiceEric R Blough
Nov 23, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Renata Swiergosz-Kowalewska, Izabela Holewa
Mar 29, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Jennifer A JamiesonCarla G Taylor
Mar 4, 2000·Environmental Health Perspectives·L Chapman, H M Chan
Apr 24, 2007·Environmental Health Perspectives·Francis W KempJohn D Bogden
Jun 13, 2012·International Journal of Environmental Research and Public Health·Ramya ChariMary A Fox
Jan 23, 2013·Journal of Mammary Gland Biology and Neoplasia·Celia ByrneMary Beth Martin
Mar 19, 2011·Ecotoxicology·Biljana BalenZeljka Vidaković-Cifrek
Aug 29, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M M Brzóska, J Moniuszko-Jakoniuk
Apr 18, 2008·Biological Trace Element Research·Zorica Plamenac BulatVesna Matović
Mar 16, 2012·Biological Trace Element Research·Mandana BarghiSeyed Mahmoud Ghasempouri
Mar 31, 2005·The American Psychologist·Susan M KogerBernard Weiss
Mar 26, 2004·Ecotoxicology and Environmental Safety·José G Dórea
Jul 26, 2012·Environmental Science and Pollution Research International·Eun-Ji WonJae-Seong Lee
Nov 13, 2012·Environmental Science and Pollution Research International·Milena VlahovićLarisa Ilijin
May 3, 2013·Environmental Science and Pollution Research International·G Smilin Bell AseervathamD Arul Ananth
Mar 30, 2013·Ecotoxicology and Environmental Safety·Jeevan R DashTapan K Mandal
Dec 4, 2012·Food Chemistry·Cláudia AfonsoMaria Leonor Nunes
Jun 24, 2011·Kidney International·Oluwatoyin F Bamgbola
Aug 11, 2011·Water Research·Avani P Naik, Chad R Hammerschmidt
Sep 21, 2010·International Journal of Hygiene and Environmental Health·Eric BeneficeRonald Lopez-Rodriguez
Dec 31, 2015·Environmental Health : a Global Access Science Source·Alejandra CantoralAdrienne S Ettinger
Jul 29, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Hasan TurkezIbrahim Kaplan
Jun 24, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Oladipo AdemuyiwaJai Raj Behari
Nov 3, 2009·Chemosphere·Kamlesh K Yadav, Sunil P Trivedi
Jun 24, 2009·Mutation Research·Kamlesh K Yadav, Sunil P Trivedi
Dec 23, 2008·Toxicology and Applied Pharmacology·Elly Suk Hen ChowShuk Han Cheng
Aug 13, 2015·Research in Veterinary Science·E A LaneS J More
Nov 17, 2007·The Science of the Total Environment·Trish J LaveryKen Sanderson
Jul 15, 2009·Basic & Clinical Pharmacology & Toxicology·Anna L B Jacob-FerreiraJose E Tanus-Santos
Mar 22, 2016·Metallomics : Integrated Biometal Science·Selvaraj RajakumarVasanthi Nachiappan
Jan 14, 2005·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Andrzej Grosicki
Feb 1, 2005·Environmental Toxicology and Pharmacology·Poonam Kakkar, Farhat N Jaffery

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