Effects of micronutrients on placental function: evidence from clinical studies to animal models

Reproduction : the Official Journal of the Society for the Study of Fertility
Bernadette C BakerRebecca L Jones

Abstract

Micronutrient deficiencies are common in pregnant women due to low dietary intake and increased requirements for fetal development. Low maternal micronutrient status is associated with a range of pregnancy pathologies involving placental dysfunction, including fetal growth restriction (FGR), small-for-gestational age (SGA), pre-eclampsia and preterm birth. However, clinical trials commonly fail to convincingly demonstrate beneficial effects of supplementation of individual micronutrients, attributed to heterogeneity and insufficient power, potential interactions and lack of mechanistic knowledge of effects on the placenta. We aimed to provide current evidence of relationships between selected micronutrients (vitamin D, vitamin A, iron, folate, vitamin B12) and adverse pregnancy outcomes, combined with understanding of actions on the placenta. Following a systematic literature search, we reviewed data from clinical, in vitro and in vivo studies of micronutrient deficiency and supplementation. Key findings are potential effects of micronutrient deficiencies on placental development and function, leading to impaired fetal growth. Studies in human trophoblast cells and rodent models provide insights into underpinning mechanisms. In...Continue Reading

References

Oct 1, 1975·The Journal of Nutrition·Y I TakahashiD S Goodman
Jun 1, 1982·The Journal of Clinical Endocrinology and Metabolism·J Y Chou
Feb 1, 1984·The Journal of Nutrition·A R Sherman, P E Moran
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·O WendlingM Mark
May 9, 2000·The American Journal of Clinical Nutrition·T O Scholl, W G Johnson
Feb 24, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·R P Steegers-TheunissenP N Baker
May 17, 2001·Molecular and Cellular Biochemistry·K SrigiridharL Singotamu
May 26, 2001·Annual Review of Nutrition·J R SuhP J Stover
Jan 24, 2002·Biology of Reproduction·Lorraine GamblingHarry J McArdle
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Patrick B WalterBruce N Ames
Jun 19, 2002·American Journal of Reproductive Immunology : AJRI·Christos AntipatisRichard G Lea
Jul 18, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·M S RadhikaB Siva Kumar
May 6, 2003·The Journal of Nutrition·Esther Casanueva, Fernando E Viteri
Jun 29, 2004·Journal of the Society for Gynecologic Investigation·Katie N EvansMartin Hewison
Aug 3, 2004·Molecular Human Reproduction·N Di SimoneA Caruso
Mar 3, 2005·American Journal of Physiology. Endocrinology and Metabolism·Christopher S KovacsJames K Friel
May 11, 2005·The American Journal of Clinical Nutrition·Theresa O Scholl
Jul 16, 2005·Clinical Microbiology Reviews·Eduardo Villamor, Wafaie W Fawzi
Oct 7, 2006·The American Journal of Clinical Nutrition·Lisa A Houghton, Reinhold Vieth
Jan 30, 2007·The Journal of Steroid Biochemistry and Molecular Biology·David BarreraLorenza Díaz
Jan 24, 2008·Reproductive Biology and Endocrinology : RB&E·David BarreraLorenza Díaz
Jun 13, 2008·The Journal of Nutritional Biochemistry·Ji-Myung KimNamsoo Chang
Aug 20, 2008·Food and Nutrition Bulletin·Bruno de Benoist
Aug 23, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·William J EvansStefan D Anker
Dec 5, 2008·Archives of Disease in Childhood·S E HåbergW Nystad
Dec 10, 2008·The American Journal of Clinical Nutrition·Anne C LookerElizabeth A Yetley
Jan 30, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lorraine GamblingHarry J McArdle
Feb 14, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Laura PickellRima Rozen
Feb 27, 2009·The American Journal of Clinical Nutrition·Philip N BakerLucilla Poston
Apr 22, 2009·Nuclear Receptor Signaling·Manuel MarkPierre Chambon
Nov 3, 2009·American Journal of Epidemiology·Melissa J WhitrowMichael J Davies
Apr 21, 2010·Obstetrical & Gynecological Survey·Lisa M Bodnar, Hyagriv N Simhan
Sep 25, 2010·Placenta·J S ShinD M Nelson
Oct 1, 2010·The Journal of Nutrition·Liv Elin TorheimMary Arimond
Jan 22, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Laura PickellRima Rozen

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Citations

Sep 2, 2018·Diabetes/metabolism Research and Reviews·Miji KimJesse Roth
Feb 18, 2020·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·María S Jaureguiberry, Andrés Venturino
Feb 8, 2020·Molecular Nutrition & Food Research·Jeffrey HoekSam Schoenmakers
Oct 2, 2020·Current Developments in Nutrition·Bryan M GannonSaurabh Mehta
Jul 13, 2020·Molecular Biology Reports·Esther Alves de Souza, Luciana Pellegrini Pisani
Jan 27, 2020·Nutrition·Juan Miguel Martínez-GalianoMiguel Delgado-Rodríguez
Sep 14, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Jessica F Hebert, Leslie Myatt
Dec 29, 2020·Clinical Therapeutics·Aisha RasoolPerrie O'Tierney-Ginn
Sep 13, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Ann-Sophie TherrienKelsey N Dancause

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