Effects of midazolam, DMCM and lindane on potentiated startle in the rat.

Psychopharmacology
T H Hijzen, J L Slangen

Abstract

Forty-eight male Wistar rats were exposed to contingent light-shock combinations and 48 rats received light and shock stimuli in a random order. One day after fear conditioning the animals were tested for startle potentiation after injection of midazolam (0, 0.5, 1.0, 2.0 mg/kg, IP) or DMCM (methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate; 0, 0.1, 0.2, 0.4 mg/kg IP) or lindane (0, 7.5, 15.0, 30.0 mg/kg PO). Midazolam attenuated potentiated startle dose dependently and the inverse benzodiazepine agonist DMCM had the opposite effect. The effects of lindane on startle amplitudes were identical to those of DMCM, indicating that lindane has anxiogenic effects on behavior. It is suggested that the anxiogenic effects of lindane are mediated by an effect at the GABA-ionophore complex.

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Citations

Jan 1, 1993·Psychopharmacology·R Trullas, P Skolnick
Jul 1, 1996·Psychopharmacology·R J JoordensB Olivier
Jan 1, 1993·Psychopharmacology·C A MorganD S Charney
May 18, 2012·Psychopharmacology·Michel A SteinerFrancois Jenck
May 1, 1990·Pharmacology, Biochemistry, and Behavior·T H HijzenJ L Slangen
Apr 1, 1991·Pharmacology, Biochemistry, and Behavior·T H HijzenJ L Slangen
May 1, 1996·Pharmacology, Biochemistry, and Behavior·S M KorteB Bohus
Dec 20, 1993·Behavioural Brain Research·M DavisM Kim
May 15, 1998·Neurotoxicology and Teratology·S RiveraC Sanfeliu
Apr 17, 2010·Pharmacology, Biochemistry, and Behavior·Elisabeth Yvonne BijlsmaLucianne Groenink
Dec 21, 2004·Biological Psychiatry·Victoria B Risbrough, Mark A Geyer
Dec 6, 2005·Pharmacology, Biochemistry, and Behavior·Shigeo MiyataJunzo Kamei
Aug 16, 2005·Neuroscience and Biobehavioral Reviews·Markus FendtIain S McGregor
Oct 11, 2005·Toxicology·Sylvie CloutierBarbara A Sorg
Jun 1, 2008·Current Protocols in Pharmacology·Lucianne GroeninkBerend Olivier

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