Effects of midazolam on explicit vs implicit memory in a pediatric surgery setting.

Psychopharmacology
Sherry H StewartTeresa Valois Gomez

Abstract

Placebo-controlled studies show that midazolam impairs explicit memory in children undergoing surgery (Buffett-Jerrott et al., Psychopharmacology 168:377-386, 2003; Kain et al., Anesthesiology 93:676-684, 2000). A recent within-subjects study showed that midazolam impaired explicit memory while leaving implicit memory intact in a sample of older children undergoing painful medical procedures (Pringle et al., Health Psychol 22:263-269, 2003). We attempted to replicate and extend these findings in a randomized, placebo-controlled design with younger children undergoing surgery. Children aged 3-6 years who were undergoing ear tube (myringotomy) surgery were randomly assigned to receive midazolam (n = 12) or placebo (n = 11). After surgery, they were tested on explicit (recognition) and implicit (priming) memory for pictures encoded before surgery. Relative to placebo, the midazolam-treated children showed poorer recognition memory on the explicit task but equivalent priming on the implicit task. Overall, it appears that midazolam induces a dissociation between explicit and implicit memory in young children in the pediatric surgery setting. Theoretical and clinical implications of the findings are discussed along with directions fo...Continue Reading

References

Jan 1, 1991·Medical and Pediatric Oncology·A G FriedmanG K Rivera
Nov 1, 1990·Anesthesiology·L H FeldP F White
Jan 1, 1990·Acta Anaesthesiologica Scandinavica. Supplementum·C Saint-MauriceI Murat
Jan 1, 1987·Psychopharmacology·C A O'BoyleC McCreary
Aug 1, 1988·Acta Anaesthesiologica Scandinavica·P C De Jong, M P Verburg
Dec 1, 1988·Anesthesiology·N C WiltonU A Pandit
Mar 1, 1981·European Journal of Clinical Pharmacology·M T SmithT O Brophy
Feb 1, 1982·Anaesthesia and Intensive Care·W H Cole
Jun 1, 1995·Journal of Experimental Child Psychology·A B Drummey, N Newcombe
Dec 1, 1996·Archives of Pediatrics & Adolescent Medicine·Z N KainD V Cicchetti
Feb 1, 1997·Anesthesia and Analgesia·Z N KainS Rimar
Jul 21, 1998·Annals of the New York Academy of Sciences·G A Dasch, L M Jackson
Jul 1, 1997·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·M P CarrS M Bauchmoyer
Mar 20, 1999·The Australian and New Zealand Journal of Psychiatry·H M van Praag
Sep 2, 2000·Anesthesiology·Z N KainJ S Reznick
Oct 21, 2000·Archives of Disease in Childhood·S PlayforI Choonara
Jan 29, 2002·Current Pharmaceutical Design·S E Buffett-Jerrott, S H Stewart
Jun 7, 2003·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Beverly PringleAllen Eskenazi
Jul 8, 2003·Psychopharmacology·Susan E Buffett-JerrottHeather Lee Loughlan
Dec 24, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·G Allen FinleyDonna Millington
Jan 10, 2006·Depression and Anxiety·Ariel J Lang, Dale E McNiel

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Citations

Mar 22, 2013·Der Anaesthesist·A Machotta, G Schneider
Dec 3, 2013·Cognitive Neurodynamics·Nasibeh TalebiTim Curran
Dec 21, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Robert D Sanders, Mervyn Maze
Sep 27, 2012·Anesthesia and Analgesia·Jeongwoo LeeSeonghoon Ko
Apr 3, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·D Cohen-Salmon
Jul 18, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Kyle S EttingerKevin Arce
May 25, 2007·Annales Françaises D'anesthèsie Et De Rèanimation·I Constant
Feb 18, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Tomorrow D WilsonRobert W Graves
May 5, 2007·Current Opinion in Anaesthesiology·Pervin Bozkurt
Jun 28, 2019·Journal of Perioperative Practice·J Lewis, C R Bailey
May 31, 2017·AORN Journal·Thomas HackmannJill Chorney
May 18, 2019·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jinsoo KimKristi D Wright
Nov 1, 2016·Paediatric Drugs·Arthura D Moore, Doralina L Anghelescu
Jul 26, 2018·Anaesthesia·V M Yuen, C R Bailey
Aug 13, 2017·Current Psychiatry Reports·Nasuh MalasSusan Turkel
Jan 19, 2021·BJA Education·S Heikal, G Stuart

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