Effects of midazolam on the threshold of lidocaine-induced seizures in the dog--comparison with diazepam

Journal of Anesthesia
H HorikawaK Ichiyanagi

Abstract

The anticonvulsive effect of midazolam was compared with that of diazepam in ten dogs. Lidocaine-induced seizure waves on the electroencephalogram were used to observe the suppressive effect of the drugs. Midazolam, 0.2 mg.kg(-1), was found to possess a stronger suppressive effect against lidocaine-induced seizures than the same dose of diazepam. These two drugs showed to possess similar effects on cerebral and systemic circulations and cerebral metabolism during seizures.

Citations

Mar 29, 2012·American Journal of Veterinary Research·Joseph S EaglesonCatherine A White
Dec 30, 2017·American Journal of Veterinary Research·Mohammed F AldawsariSimon R Platt
Jan 31, 2014·Journal of Clinical Nursing·Fatima Al SayahBeverly Williams
Jul 19, 2017·Hand : Official Journal of the American Association for Hand Surgery·Richard W GurichJohn L Sanders

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