Effects of middle ear oxygen and carbon dioxide tensions on eustachian tube ventilatory function

The Laryngoscope
A ShupakW J Doyle

Abstract

The objective of this study was to determine the effect of middle ear (ME) gas composition on eustachian tube ventilatory function (ETVF). ETVF was evaluated by using forced-response and inflation-de-flation tests in four alert cynomolgus monkeys during test sessions with different gas compositions. The ME was flushed with one of the four gas mixtures: 1. air; 2. 12% oxygen, 88% nitrogen; 3. 100% oxygen; and 4. 5% carbon dioxide, 21% oxygen, and 74% nitrogen before and during testing. The results documented lower opening, steady-state, and closing pressures, lower passive and active resistance, and greater dilatory efficiency following ME flushes with the hypercarbic and hypoxic gas mixtures when compared to the others. Also, for applied ME overpressure, the maximum pressure change during a swallow, the average pressure drop for all swallows, and the percentage of the applied pressure equalized were greater under hypoxic and hypercarbic conditions. These results show that ME gas composition affects ETVF and support feedback modulation of ME pressure regulation.

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Citations

Apr 18, 2000·International Journal of Pediatric Otorhinolaryngology·M BunneB Magnuson
Oct 23, 1997·The Laryngoscope·A ShupakW J Doyle
Jul 26, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Till S MutzbauerKay Tetzlaff
Oct 3, 2007·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Avi Shupak
Jan 10, 2016·Journal of the Royal Army Medical Corps·Jonathan Bt Herron
Apr 7, 2020·High Altitude Medicine & Biology·Avi Shupak

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