Effects of midline and lateral cerebellar lesions on motor coordination and spatial orientation

Brain Research
C C JoyalR Lalonde

Abstract

Rats were lesioned in the midline cerebellum, comprising the vermis and fastigial nucleus, or the lateral cerebellum, comprising the cerebellar hemispheres and dentate nucleus, and evaluated in a series of motor and non-motor learning tests. Rats with midline lesions had difficulty in maintaining their equilibrium on a bridge and were slower before turning upward and traversed less squares on an inclined grid. They were not impaired for muscle strength when suspended from a horizontal wire. Rats with lateral lesions had milder deficits on the bridge and were not affected in the other two tests. In the Morris water maze test, rats with lateral lesions were deficient in spatial orientation, whereas rats with midline lesions were deficient in visuomotor coordination. Lateral lesions had no effects on visual discrimination learning. These results illustrate the differential influence of midline as opposed to lateral cerebellar regions on both motor and non-motor behaviors. Fastigial nucleus lesions decreased the time spent in equilibrium and latencies before falling on the bridge and the distance travelled along the inclined grid but had no effect on muscle strength when suspended from the horizontal string. Quadrant entries and es...Continue Reading

References

Mar 1, 1992·Neuroscience Research·P Brodal, J G Bjaalie
Oct 1, 1992·Behavioral Neuroscience·R A SwainR F Thompson
Dec 11, 1991·Behavioral Neuroscience·R N Leaton, W F Supple
Sep 1, 1990·Brain Research. Brain Research Reviews·R Lalonde, M I Botez
Jun 1, 1989·Behavioural Brain Research·D G Lavond, J E Steinmetz
Jun 1, 1989·Italian Journal of Neurological Sciences·M I BotezE Attig
Dec 18, 1987·Science·J R Bloedel
Aug 29, 1986·Science·R F Thompson
Jan 1, 1972·Progress in Brain Research·F Walberg
Apr 28, 1972·Brain Research·N Doba, D J Reis
Feb 1, 1967·Psychological Bulletin·B J Fellows
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Mar 14, 1994·Brain Research·R Lalonde
Jan 1, 1993·European Neurology·T Botez-Marquard, M I Botez
Oct 1, 1993·Behavioral Neuroscience·I DaumN Birbaumer
May 14, 1993·Science·D J KrupaR F Thompson
Dec 18, 1987·Science·R F Thompson
Apr 1, 1994·Journal of Cognitive Neuroscience·P DeanP Langdon

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Citations

Feb 26, 2013·Cellular and Molecular Neurobiology·Wanda M SnowJudy E Anderson
Oct 10, 1998·Brain Research·J CastonJ Mariani
May 4, 2001·Behavioural Brain Research·C C JoyalR Lalonde
Mar 23, 2004·Behavioural Brain Research·Alena Krízková, Frantisek Vozeh
Oct 1, 1998·Behavioural Brain Research·J CastonJ Mariani
Nov 24, 2001·Neuroscience·C C Wrenn, R G Wiley
Aug 23, 2003·Behavioral Neuroscience·Kurtis L Noblett, Rodney A Swain
Jun 2, 2011·The Journal of Biological Chemistry·Davina V GutierrezStefan Herlitze
Dec 31, 1997·The European Journal of Neuroscience·M MolinariL Petrosini
Feb 13, 2003·Annals of the New York Academy of Sciences·Hanneke I Van Mier, Steve E Petersen
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·M G LeggioL Petrosini
Sep 1, 1998·Trends in Cognitive Sciences·W T Thach
Jan 5, 2011·Neurobiology of Learning and Memory·David J BauerRodney A Swain
Sep 28, 2010·Brain Research·Caroline C RealRaquel S Pires
Nov 19, 2003·The European Journal of Neuroscience·Loren A MartinGuy Mittleman
Mar 8, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Crystal L MurciaKarl Herrup
Nov 15, 2011·Journal of Tissue Engineering and Regenerative Medicine·Eun-Ju KangGyu-Jin Rho
Dec 12, 2012·Behavioural Brain Research·Stijn StroobantsRudi D'Hooge
Nov 5, 2013·Behavioural Brain Research·Emilio DuránCosme Salas
Apr 30, 2016·Behavioural Brain Research·Samira SalameRaquel S Pires
May 3, 2016·Biomolecules & Therapeutics·Ki Chan KimChan Young Shin
Jan 16, 2007·Progress in Neurobiology·R Lalonde, C Strazielle
May 3, 2006·Journal of Neuropathology and Experimental Neurology·Eugene ParkAndrew J Baker
Sep 13, 2018·Scientific Reports·Gokhan OrdekMesut Sahin
Mar 2, 2019·The Cerebellum·Robert Lalonde, Catherine Strazielle

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