PMID: 61715Sep 1, 1976Paper

Effects of midodrine, ST 1059, methoxamine and glycine on spontaneously beating guinea-pig atria

Agents and Actions
H Pittner

Abstract

The chronotropic effects of midodrine, glycine (10(-8) to 3.10(-3) M), ST1059 and methoxamine (10(-8) to 10(-3) M) were investigated in the spontaneously beating guinea-pig right atrial preparation. Midodrine and glycine produced a slight, but significant rise in atrial rate over a wide concentration range. The midodrine-induced rise in atrial rate was not influenced by the beta-adrenergic receptor blocking drug propranolol (10(-6) M). The histamine (H2)-receptor blocking drug metiamide (3.10(-5) M) abolished the positive chronotropic actions of both midodrine and glycine. No positive chronotropic effect was seen after the administration of ST 1059 or methoxamine. A decrease in atrial rate was elicited by high concentrations (above 10(-4) to 10(-3) M) of the sympathomimetic agents midodrine, ST 1059, and methoxamine, but not by the amino acid glycine.

References

Apr 1, 1975·British Journal of Pharmacology·A J HoodD F Weetman
Oct 1, 1973·Agents and Actions·J W BlackJ H Wyllie
Apr 5, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·A Csongrady, W Kobinger
Apr 21, 1972·Nature·J W BlackE M Parsons
Apr 21, 1964·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·J R BLINKS
Jun 1, 1948·The American Journal of Physiology·R P AHLQUIST

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