PMID: 41262Aug 1, 1979

Effects of MIF-I and melatonin on novelty-induced defecation and associated plasma 11-OHCS and brain catecholamines

Pharmacology, Biochemistry, and Behavior
P C Datta, M G King


In two experiments the effects were investigated of MSH-inhibiting factor-I (MIF-I) and of Melatonin on step-down latencies, defection, plasma 11-OHCS levels, whole brain DA and whole brain NE concentrations on Days 1, 3 and 5 of novelty exposure. Treatment with MIF-I led to a significant habituation of novelty-induced defecation over 5 days, whereas plasma 11-OHCS level was reduced only on Day 1. The concentrations of whole brain DA and whole brain NE also showed a significant increase over days of MIF-I and novelty treatment. Melatonin treatment, on the other hand, significantly inhibited novelty-induced defecation and reduced plasma 11-OHCS level on Day 5 of novelty exposure. Melatonin treatment led to a significant increase of whole brain DA in animals exposed to novelty for 5 days. Neither MIF-I nor Melatonin was found to significantly affect the step-down activity of treated animals. The overall results suggested a possible relationship between novelty-induced defecation and brain DA levels of MIF-I and Melatonin treated animals.


Nov 1, 1975·Pharmacology, Biochemistry, and Behavior·M A SpirtesA J Kastin
Jan 1, 1976·Pharmacology, Biochemistry, and Behavior·R H Ehrensing, A J Kastin
Apr 1, 1977·Pharmacology, Biochemistry, and Behavior·P C Datta, M G King
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Jun 18, 1971·Biochemical and Biophysical Research Communications·R M NairA V Schally
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Jun 24, 1992·European Journal of Pharmacology·C Durlach-Misteli, J M van Ree
Dec 1, 1981·Pharmacology, Biochemistry, and Behavior·P Golus, M G King
Jan 1, 1980·Neuroscience and Biobehavioral Reviews·P C Datta, M G King
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·T K von AlmenR D Olson
Jan 1, 1982·Pharmacology & Therapeutics·D H Versteeg
Jan 1, 1981·Peptides·P C DattaC A Sandman
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·B H Herman
Aug 26, 1999·Pharmacology, Biochemistry, and Behavior·C KoppR Misslin
Jun 12, 2013·Chronobiology International·Carmel Bilu, Noga Kronfeld-Schor

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