PMID: 41262Aug 1, 1979

Effects of MIF-I and melatonin on novelty-induced defecation and associated plasma 11-OHCS and brain catecholamines

Pharmacology, Biochemistry, and Behavior
P C Datta, M G King

Abstract

In two experiments the effects were investigated of MSH-inhibiting factor-I (MIF-I) and of Melatonin on step-down latencies, defection, plasma 11-OHCS levels, whole brain DA and whole brain NE concentrations on Days 1, 3 and 5 of novelty exposure. Treatment with MIF-I led to a significant habituation of novelty-induced defecation over 5 days, whereas plasma 11-OHCS level was reduced only on Day 1. The concentrations of whole brain DA and whole brain NE also showed a significant increase over days of MIF-I and novelty treatment. Melatonin treatment, on the other hand, significantly inhibited novelty-induced defecation and reduced plasma 11-OHCS level on Day 5 of novelty exposure. Melatonin treatment led to a significant increase of whole brain DA in animals exposed to novelty for 5 days. Neither MIF-I nor Melatonin was found to significantly affect the step-down activity of treated animals. The overall results suggested a possible relationship between novelty-induced defecation and brain DA levels of MIF-I and Melatonin treated animals.

References

Nov 1, 1975·Pharmacology, Biochemistry, and Behavior·M A SpirtesA J Kastin
Jan 1, 1976·Pharmacology, Biochemistry, and Behavior·R H Ehrensing, A J Kastin
Apr 1, 1977·Pharmacology, Biochemistry, and Behavior·P C Datta, M G King
Jan 1, 1975·Pharmacology, Biochemistry, and Behavior·B K BernardD A Yutzey
Jun 18, 1971·Biochemical and Biophysical Research Communications·R M NairA V Schally
Jan 1, 1974·Archives of General Psychiatry·R H Ehrensing, A J Kastin
Jan 1, 1973·Neuroendocrinology·N P PlotnikoffA V Schally
Nov 23, 1973·Science·E FriedmanS Gershon
May 1, 1974·Pharmacology, Biochemistry, and Behavior·N P Plotnikoff, A J Kastin
Jan 1, 1969·Endocrinology·A J KastinM C Miller
Nov 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·N P PlotnikoffA V Schally
Apr 7, 1967·Science·J J Schildkraut, S S Kety
Aug 1, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·F Anton-TayA Fernández-Guardiola
Apr 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·A J KastinA V Schally
May 27, 1967·Nature·J BarchasS Spector

Citations

Jun 24, 1992·European Journal of Pharmacology·C Durlach-Misteli, J M van Ree
Dec 1, 1981·Pharmacology, Biochemistry, and Behavior·P Golus, M G King
Jan 1, 1980·Neuroscience and Biobehavioral Reviews·P C Datta, M G King
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·T K von AlmenR D Olson
Jan 1, 1982·Pharmacology & Therapeutics·D H Versteeg
Jan 1, 1981·Peptides·P C DattaC A Sandman
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·B H Herman
Aug 26, 1999·Pharmacology, Biochemistry, and Behavior·C KoppR Misslin
Jun 12, 2013·Chronobiology International·Carmel Bilu, Noga Kronfeld-Schor

Related Concepts

Metazoa
Brain Chemistry
Catecholamines
Defecation
Impacts, Environmental
Melatonin
MSH Release-Inhibiting Hormone
11-Hydroxycorticosteroids
Rats, Laboratory

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