Effects of Mild Chronic Intermittent Cold Exposure on Rat Organs

International Journal of Biological Sciences
Xiaohui WangWenjing Luo

Abstract

Cold adaptation is a body's protective response to cold stress. Mild chronic intermittent cold (CIC) exposure has been used to generate animal models for cold adaptation studies. However, the effects of mild CIC exposure on vital organs are not completely characterized. In the present study, we exposed rats to mild CIC for two weeks, and then measured the body weights, the weights of brown adipose tissue (BAT), the levels of ATP and reactive oxygen species (ROS) in the brains, livers, hearts, muscles and BATs. Rats formed cold adaptation after exposure to CIC for two weeks. Compared to rats of the control group that were hosted under ambient temperature, rats exposed to mild CIC showed a lower average body weight, but a higher weight of brown adipose tissue (BAT). Rats exposed to CIC for two weeks also exhibited higher levels of ATP and ROS in all examined organs as compared to those of the control group. In addition, we determined the expression levels of cold-inducible RNA binding protein (Cirbp) and thioredoxin (TRX) in rat tissues after 2 weeks of CIC exposure. Both Cirbp and TRX were increased, suggesting a role of these two proteins for establishment of cold adaptation. Together, this study reveals the effects of mild CIC...Continue Reading

Citations

May 6, 2016·Cellular and Molecular Life Sciences : CMLS·Xinzhou ZhuSven Wellmann
Jan 16, 2019·Journal of Leukocyte Biology·Monowar AzizPing Wang
Nov 15, 2017·Future Science OA·Peng Zhong, He Huang
Sep 15, 2018·Oncology Letters·Tongbai XuYanhua Chen
May 5, 2017·Neural Regeneration Research·Ting-Ting QuJin-Bo Deng
Feb 26, 2019·Therapeutic Hypothermia and Temperature Management·Travis C Jackson, Patrick M Kochanek
Oct 1, 2019·International Heart Journal·Liu Yuxiang, Katsuhito Fujiu
Jan 15, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Agustina CreusYolanda Bolzón de Lombardo
Apr 16, 2020·Reproductive Biology and Endocrinology : RB&E·Di WangCairui Yang
Feb 16, 2021·Frontiers in Physiology·Wioleta Dudzinska, Anna Lubkowska
May 16, 2021·Protein Science : a Publication of the Protein Society·Qishun ZhouTobias Madl

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Methods Mentioned

BETA
Assay
PCR
electrophoresis
Protein Assay

Software Mentioned

Cirbp

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