PMID: 11605935Oct 19, 2001Paper

Effects of mild hypothermia on blood-brain barrier disruption during isoflurane or pentobarbital anesthesia

Anesthesiology
O Z ChiH R Weiss

Abstract

This study was performed to determine whether mild hypothermia (32 degrees C) could attenuate the degree of blood-brain barrier (BBB) disruption caused by a hyperosmolar solution and whether the degree of disruption would vary depending on anesthetic agents. Rats were assigned to one of four groups: normothermic isoflurane, normothermic pentobarbital, hypothermic isoflurane, and hypothermic pentobarbital. During isoflurane (1.4%; normothermic or hypothermic) or pentobarbital (50 mg/kg administered intraperitoneally; normothermic or hypothermic) anesthesia, the external carotid artery and the femoral artery and vein were catheterized. Body temperature was maintained at 37 and 32 degrees C for the normothermic and hypothermic groups, respectively. To open the BBB, 25% mannitol was infused through the right carotid artery at the rate of 0.25 ml x kg(-1) x s(-1) for 30 s. The transfer coefficient of 14C-alpha-aminoisobutyric acid was determined. Blood pressure was similar among the four groups of animals. The degree of the BBB disruption by hyperosmolar mannitol was less with isoflurane than pentobarbital anesthesia in the normothermic groups (transfer coefficient: 29.9 +/- 17.1 and 50.4 +/- 17.5 microl x g(-1) x min(-1) for normot...Continue Reading

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Citations

Mar 3, 2005·Der Anaesthesist·A BrüxK H Polderman
Jun 26, 2009·Critical Care Medicine·Kees H Polderman
Jan 30, 2013·Journal of the Neurological Sciences·Oak Z ChiHarvey R Weiss
Oct 27, 2012·Annales de cardiologie et d'angéiologie·C Delhaye, G Lemesle
May 26, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Paul McCarthyAlireza Minagar
Jun 16, 2015·Therapeutic Hypothermia and Temperature Management·Brian K CechmanekPhilip A Barber
Feb 27, 2009·Acta Anaesthesiologica Scandinavica·M CastrénUNKNOWN Task Force on Scandinavian Therapeutic Hypothermia Guidelines, Clinical Practice Committee Scandinavian Society of Anaesthes
Oct 26, 2005·Journal of Hepatology·Javier VaqueroRoger F Butterworth
Jan 14, 2012·Journal of the American College of Cardiology·Cédric DelhayeRon Waksman
Aug 23, 2008·Anesthesiology·Shailendra JoshiEugene Ornstein
May 7, 2010·Journal of Intensive Care Medicine·Robert A Finkelstein, Hasan B Alam
Aug 4, 2012·World Journal of Critical Care Medicine·Jesse J Corry
Jul 15, 2017·World Journal of Methodology·Sombat Muengtaweepongsa, Winchana Srivilaithon
Oct 14, 2017·Journal of the Royal Army Medical Corps·James Collis
Jun 21, 2017·Annals of Intensive Care·Alain CariouUNKNOWN Société de Réanimation de Langue Française (SRLF) and the Société Française d’Anesthésie et de Réanimation (SFAR) In conjunc
Feb 23, 2020·Critical Care Nursing Quarterly·Michael J ArmahizerMehrnaz Pajoumand
Oct 5, 2020·Seizure : the Journal of the British Epilepsy Association·Bence CsernyusAnita Pongrácz

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