Effects of mild hypothermia on hemodynamics in cardiac arrest survivors and isolated failing human myocardium.

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Claudius JacobshagenL S Maier

Abstract

Post-cardiac arrest myocardial dysfunction is a common phenomenon after return of spontaneous circulation (ROSC) and contributes to hemodynamic instability and low survival rates after cardiac arrest. Mild hypothermia for 24 h after ROSC has been shown to significantly improve neurologic recovery and survival rates. In the present study we investigate the influence of therapeutic hypothermia on hemodynamic parameters in resuscitated patients and on contractility in failing human myocardium. We analyzed hemodynamic data from 200 cardiac arrest survivors during the hypothermia period. The initial LVEF was 32.6 +/- 1.2% indicating a significantly impaired LV function. During hypothermia induction, the infusion rate of epinephrine could be significantly reduced from 9.1 +/- 1.3 microg/min [arrival intensive care unit (ICU) 35.4 degrees C] to 4.6 +/- 1.0 microg/min (34 degrees C) and 2.8 +/- 0.5 microg/min (33 degrees C). The dobutamine and norepinephrine application rates were not changed significantly. The mean arterial blood pressure remained stable. The mean heart rate significantly decreased from 91.8 +/- 1.7 bpm (arrival ICU) to 77.3 +/- 1.5 bpm (34 degrees C) and 70.3 +/- 1.4 bpm (33 degrees C). In vitro we investigated the e...Continue Reading

References

Jun 1, 1996·Critical Care Medicine·R J GazmuriD McKee
Mar 31, 2001·Intensive Care Medicine·A Karimova, D J Pinsky
May 1, 2001·Basic Research in Cardiology·J WeisserB Pieske
Aug 30, 2001·American Heart Journal·G M Felker, C M O'Connor
Jan 5, 2002·Journal of the American College of Cardiology·Michael E LewisRobert S Bonser
Feb 22, 2002·The New England Journal of Medicine·UNKNOWN Hypothermia after Cardiac Arrest Study Group
Feb 22, 2002·The New England Journal of Medicine·Stephen A BernardKaren Smith
Jul 31, 2002·Circulation·Christophe AdrieJean-Marc Cavaillon
Sep 18, 2002·Journal of Molecular and Cellular Cardiology·Gerd Hasenfuss, Burkert Pieske
Dec 31, 2002·Journal of the American College of Cardiology·Ivan LaurentJean-François Dhainaut
Aug 5, 2003·The American Journal of Emergency Medicine·Martin FredrikssonG Nichol
Sep 15, 2004·Intensive Care Medicine·Stephen LaverJerry Nolan
Feb 9, 2005·Critical Care Medicine·Michael HolzerUNKNOWN Collaborative Group on Induced Hypothermia for Neuroprotection After Cardiac Arrest
Aug 2, 2005·Resuscitation·Manuel Ruiz-BailénJavier Fierro-Rosón
Jan 5, 2006·JAMA : the Journal of the American Medical Association·Vinay M NadkarniUNKNOWN National Registry of Cardiopulmonary Resuscitation Investigators
Jul 27, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·K ReinhartK Werdan
Jun 27, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·J-C Reil, M Böhm
Aug 28, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·C NalenzH-J Rupprecht
Sep 18, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·S HettwerK Werdan
May 17, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Margit StraussUNKNOWN MITRA Plus Study Group
May 21, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Marianne DebrunnerJürgen Frielingsdorf
May 31, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christian StormDietrich Hasper
Jul 16, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christian JungHans-Reiner Figulla
Sep 4, 2008·Circulation·Christopher B Overgaard, Vladimír Dzavík
Sep 25, 2008·JAMA : the Journal of the American Medical Association·Graham NicholUNKNOWN Resuscitation Outcomes Consortium Investigators
Jan 20, 2009·Cardiovascular Research·Theodore P AbrahamDanuta Szczesna-Cordary
Feb 12, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Thomas HerrenFirat Duru
Mar 13, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Kayan LamBas A J M de Mol
Apr 16, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christian JungMarkus Ferrari
Jul 3, 2009·The New England Journal of Medicine·William J EhlenbachRenee D Stapleton

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Citations

May 12, 2012·Der Anaesthesist·A SchneiderP Teschendorf
Apr 9, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·R PfeiferA Voss
Jun 22, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Ralf KoesterStefan Kluge
Nov 4, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Nadine Abanador-KamperMelchior Seyfarth
Feb 11, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Obaida R RanaErol Saygili
May 9, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Eva S KehmeierTienush Rassaf
Jun 26, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Gregor SimonisRuth H Strasser
Feb 25, 2011·Critical Care : the Official Journal of the Critical Care Forum·Paul Steendijk
Sep 24, 2013·Best Practice & Research. Clinical Anaesthesiology·Kjetil Sunde
Apr 30, 2014·Revista Española De Cardiología·Kjetil Sunde
Dec 14, 2011·Resuscitation·Xinrong HeJean-Louis Vincent
Dec 17, 2015·Best Practice & Research. Clinical Anaesthesiology·Tommaso PellisGiuseppe Ristagno
Jan 21, 2011·Orvosi hetilap·Eniko KovácsEndre Zima
Sep 12, 2014·Neurocritical Care·Fabio Silvio TacconeUNKNOWN Participants in the International Multi-disciplinary Consensus Conference on Multimodality Monitoring
May 18, 2016·Anaesthesia Critical Care & Pain Medicine·Fanny VardonOlivier Fourcade
Dec 31, 2015·European Heart Journal. Acute Cardiovascular Care·Luis O ChavezJoseph Varon
Dec 29, 2013·Journal of Intensive Care Medicine·Adam M Noyes, Justin B Lundbye
Apr 11, 2012·Critical Care Medicine·Carsten ZobelHannes Reuter
Mar 21, 2013·Critical Care : the Official Journal of the Critical Care Forum·Raphaël GiraudKarim Bendjelid
Aug 22, 2013·Critical Care Medicine·Michael SchwarzlHeiner Post
Jul 12, 2011·Current Opinion in Critical Care·Jerry P Nolan
Apr 19, 2011·Current Opinion in Critical Care·Jerry P Nolan
Feb 24, 2015·Critical Care Medicine·Henrik Stær-JensenGeir Øystein Andersen
Apr 5, 2011·Current Opinion in Critical Care·Kjetil Sunde, Eldar Søreide
Mar 8, 2011·Current Opinion in Critical Care·Ayhan Zia, Karl B Kern
Mar 5, 2021·Frontiers in Cardiovascular Medicine·Kelly P YamadaKiyotake Ishikawa
Mar 27, 2021·Journal of Molecular and Cellular Cardiology·Mohammed A MashaliPaul M L Janssen

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