Effects of milk powder intervention on bone mineral density and indicators related to bone metabolism in Chinese adolescents

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
J X LuQian Zhang

Abstract

The study is to determine the effects of milk powder on bone density and metabolism in healthy adolescents. Vitamin D and calcium supplements increased IGF-1 but did not affect bone mineralization or turnover. Higher vitamin D in combination with sufficient calcium supplementation in such populations requires attention. Both calcium and vitamin D play an important role in bone mineralization in adolescents. In this one and a half-year randomized controlled trial, 232 participants (aged 12-15 years) were randomly assigned to three intervention groups receiving milk powder fortified with vitamin D 400 IU plus calcium 300, or 600, or 900 mg [Ca3D (n = 54), Ca6D (n = 56), and Ca9D (n = 49)], or one control group maintaining habitual diet [control (n = 73)]. Bone turnover markers, serum intact PTH, 25(OH)D, and IGF-1 levels were measured at baseline and one and a half years, and bone mineral contents and bone areal mineral density were measured by Dual-energy X-ray absorptiometry (DXA) at baseline, one year, and one and a half years. Baseline average serum 25(OH)D level and calcium intake were 29.4 nmol/L and 363.5 mg/day, respectively. There was a significant increase in bone turnover, total body, hip, lumbar spine bone mineral den...Continue Reading

References

Jul 19, 1992·The New England Journal of Medicine·C C JohnstonM Peacock
Jul 4, 1998·Journal of Internal Medicine·J O KristinssonL Steingrimsdottir
Nov 27, 2002·The American Journal of Clinical Nutrition·Marjo K M Lehtonen-VeromaaJorma S A Viikari
Oct 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Melissa A CameronJohn D Wark
Mar 10, 2005·The Journal of Clinical Endocrinology and Metabolism·Ann PrenticeTim J Cole
Mar 23, 2005·Archives of Disease in Childhood·J H DaviesJ W Gregory
Jun 18, 2005·The Proceedings of the Nutrition Society·Alexis M Willett
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Feb 9, 2008·The American Journal of Clinical Nutrition·Helen L LambertMargo E Barker
Apr 11, 2008·The American Journal of Clinical Nutrition·Kevin D CashmanMairead Kiely
May 26, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Laure EsterleMichèle Garabedian
Dec 25, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S VasikaranUNKNOWN IOF-IFCC Bone Marker Standards Working Group
Jan 27, 2011·BMJ : British Medical Journal·Tania WinzenbergGraeme Jones
May 19, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kun ZhuRichard L Prince
May 16, 2012·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·G BedogniS Cianfarani
Oct 1, 2014·Pediatrics·Neville H GoldenUNKNOWN Committee on Nutrition
Mar 25, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T F CheungT P Lam

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Citations

Sep 15, 2020·Critical Reviews in Food Science and Nutrition·Taylor C WallaceConnie M Weaver

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Methods Mentioned

BETA
X-ray
ELISA

Software Mentioned

SAS
Norland

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