Effects of milk product intake on thigh muscle strength and NFKB gene methylation during home-based interval walking training in older women: A randomized, controlled pilot study

PloS One
Shizue MasukiHiroshi Nose

Abstract

Muscle atrophy with aging is closely associated with chronic systemic inflammation and lifestyle-related diseases. In the present study, we assessed whether post-exercise milk product intake during 5-month interval walking training (IWT) enhanced the increase in thigh muscle strength and ameliorated susceptibility to inflammation in older women. Subjects [n = 37, 66±5 (standard deviation) yrs] who had been performing IWT for >6 months participated in this study. They were randomly divided into the following 3 groups: IWT alone (CNT, n = 12), IWT + low-dose post-exercise milk product intake (LD, n = 12; 4 g protein and 3 g carbohydrate) or IWT + a 3-times higher dose of milk product intake than the LD group (HD, n = 13). They were instructed to repeat ≥5 sets of fast and slow walking for 3 min each at ≥70% and 40% peak aerobic capacity for walking, respectively, per day for ≥4 days/week. After IWT, thigh muscle strength increased in the HD group (8±2%) more than in the CNT group (-2±3%, P = 0.022), despite similar IWT achievements between the groups (P>0.15). Pyrosequencing analysis using whole blood showed that methylation of NFKB1 and NFKB2, master genes of inflammation, was enhanced in the HD group (29±7% and 44±11%, respecti...Continue Reading

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Citations

Aug 28, 2019·Journal of Strength and Conditioning Research·Hideaki KumaharaTakako Yamato
Sep 2, 2017·Medicine and Science in Sports and Exercise·Koji UchidaHiroshi Nose
Oct 20, 2017·Frontiers in Medicine·Mohammad Mosaferi ZiaaldiniZsolt Murlasits
Oct 11, 2020·BMC Research Notes·Saba MohammadpourSakineh Shab-Bidar
Nov 25, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Omar Ramos-LopezJ Alfredo Martinez

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Datasets Mentioned

BETA
GSE76503

Methods Mentioned

BETA
Assay
PCR
chip
biopsies

Software Mentioned

GenomeStudio
SPSS Statistics
PyroMark Q24
PyroMark Assay Design

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