Effects of mineralocorticoid receptor stimulation via fludrocortisone on memory in women with borderline personality disorder

Neurobiology of Learning and Memory
Katja WingenfeldChristian Otte

Abstract

In a previous study, we found that in contrast to healthy controls, hydrocortisone administration had enhancing effects on memory in patients with borderline personality disorder (BPD). Because hydrocortisone acts on glucocorticoid receptors (GR) and mineralocorticoid receptors (MR), it is unclear which receptor mediated these effects. The aim of the current study was to test whether more selective MR stimulation with fludrocortisone improves memory in BPD. In a placebo-controlled, randomized, within-subject, cross-over study, 39 medication-free women with BPD and 39 healthy women received placebo or 0.4mg fludrocortisone prior to cognitive testing. We measured verbal memory, visuospatial memory, and working memory. We found a significant group by fludrocortisone interaction on verbal memory and visuospatial memory. In both tests patients with BPD, but not healthy women, had impaired memory performance after fludrocortisone compared to placebo. In contrast, working memory was improved after fludrocortisone compared to placebo in both groups. Contrary to our hypothesis, we found impairing effects of MR stimulation on hippocampus-mediated verbal memory and visuospatial memory in BPD but not in healthy controls. In contrast, worki...Continue Reading

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Citations

Jan 25, 2016·Trends in Cognitive Sciences·Susanne VogelLars Schwabe
Sep 8, 2015·Journal of Psychiatric Research·Christian OtteKim Hinkelmann
Nov 9, 2016·Psychoneuroendocrinology·Christian Eric DeuterChristian Otte
Feb 23, 2019·European Journal of Psychotraumatology·Moritz DuesenbergKatja Wingenfeld
May 6, 2020·The Cochrane Database of Systematic Reviews·Ole Jakob StorebøErik Simonsen

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