PMID: 14325877Mar 1, 1965

EFFECTS OF MINERALS ON NEOMYCIN PRODUCTION BY STREPTOMYCES FRADIAE

Applied Microbiology
M K Majumdar, S K Majumdar

Abstract

A study was made on the mineral requirements of Streptomyces fradiae strain 3535 for neomycin production. It was observed that optimal levels of the elements Ca, Fe, and Zn per milliliter of a synthetic medium for neomycin production were 10.8, 1.0, and 0.115 mug, respectively. K(2)HPO(4) was required at a concentration of 0.1% for maximal yield of neomycin, whereas NaCl and the metals Mn and Cu were without any effect. High doses of Zn (0.23 mug/ml or above) caused destruction of neomycin after the fifth day of fermentation.

Related Concepts

Calcium
Calcium Chloride, Anhydrous
Copper
Fermentation
Hydrogen-Ion Concentration
Iron
Manganese
Catabolism
Neomycin Palmitate
Pharmacology

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