Effects of miR-200a and FH535 combined with taxol on proliferation and invasion of gastric cancer

Pathology, Research and Practice
Xi LiuQingyu Zhang

Abstract

Gastric cancer is one of the most common cancers in the world; taxol displayed modest efficacy as first-line chemotherapy for gastric cancer, conversely, it has limitations used alone. β-catenin is a multifunctional oncogenic protein and the elevation in expression and activity of β-catenin has been implicated in many cancers. Therefore, we assume that the inhibition of β-catenin can enhanced the efficacy of taxol. The purpose of this study was to investigate the inhibitory effect of miR-200a mimics, FH535 combined with taxol on proliferation and invasion of human gastric cancer cell lines SGC-7901 and BGC-823. In the current study, we identified that the combination of FH535 and miR-200a with taxol had potent growth-inhibitory and pro-apoptotic effects. Further, similar results were also observed in vivo, intratumoral injection of FH535, taxol and miR-200a mimics which also delayed tumor growth in nude mice harboring subcutaneous SGC-7901 xenografts. Collectively, miR-200a and FH535 can enhance the inhibitory effect of taxol on cell proliferation and moderate the invasion of human gastric cancer.

Citations

Nov 5, 2020·Diagnostics·Fatimat KipkeevaAlexander Karpukhin
Dec 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Julia Gallego-JaraTeresa de Diego Puente

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