PMID: 9529284Apr 7, 1998Paper

Effects of misalignment between transmission and emission scans on attenuation-corrected cardiac SPECT

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
I MatsunariMarkus Schwaiger

Abstract

Misalignment between transmission and emission scans in attenuation-corrected (AC) cardiac SPECT can introduce errors of measured activity. The severity of these errors, however, has not yet been fully elucidated. We performed a phantom measurement as well as a study of patients with low likelihood of coronary artery disease. Transmission and emission scans were acquired using a triple-head SPECT system with a collimated 241Am line source and an offset fanbeam collimator. The left ventricular myocardium was divided into five segments, and the mean regional activity was calculated for each segment using a semiquantitative polar map approach. Misalignment between transmission and emission data was created by shifting the emission data along the x, y or z axis. In the heart phantom, a shift between the transmission and emission data produced a decrease or increase in relative regional activity in each segment resulting in heterogeneous activity distribution. A 7-mm (1-pixel) shift produced up to 15% change in relative regional activity, suggesting that even a small misalignment between transmission and emission data can produce serious errors in measured activity. In the clinical data, the effects of misalignment were less signifi...Continue Reading

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