PMID: 9181350Jan 1, 1996Paper

Effects of mitomycin C on the rat retina

Documenta Ophthalmologica. Advances in Ophthalmology
S KawashimaT Kimura

Abstract

To evaluate the retinal toxicity of mitomycin C injection in the rat eye, we conducted an electroretinographic study and a histopathologic study. Three different concentrations of mitomycin C (0.2, 0.3 and 0.4 mg/ml) were injected into either the vitreous cavity or the anterior chamber of the experimental eyes. A full-field electroretinogram was recorded before injection and 2, 4 and 7 days after injection. The retinas of all eyes were examined by light and electron microscopy. We found no evidence of electroretinographic and histologic changes 2 and 7 days after injection of 0.4 mg/ml of mitomycin C into the anterior chamber. However, profound electroretinographic changes did follow injection of the drug into the vitreous. These were absent with the 0.2-mg/ml solution at 7 days, mild with the 0.3-mg/ml solution at 7 days and profound with the 0.4-mg/ml solution as early as 2 days. Intravitreal injection of 0.4 mg/ml, however, showed selective degeneration of Müller cell process at day 2, retinal pigment epithelium changes at day 4 and irregular arrangement of the outer nuclear layer and photoreceptors at day 7. Intravitreal injection of mitomycin C in a concentration comparable to the one used clinically could cause retinal di...Continue Reading

References

Aug 1, 1992·Archives of Ophthalmology·H D JampelC Dibernardo
Jan 1, 1992·Ophthalmology·L R PasqualeH D Jampel
Dec 1, 1991·Archives of Ophthalmology·R J DerickH Jampel
Dec 1, 1991·Archives of Ophthalmology·T J BergstromV M Elner
Mar 1, 1991·Ophthalmology·S S Palmer
Jan 1, 1991·Journal of Ocular Pharmacology·M R WilsonF Wooten
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Feb 1, 1995·Archives of Ophthalmology·C KeeP L Kaufman
Sep 15, 1993·American Journal of Ophthalmology·P T ZachariaJ S Schuman

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Citations

Jan 6, 2011·Basic & Clinical Pharmacology & Toxicology·Maria V PapadopoulouWilliam D Bloomer
Feb 17, 2018·International Journal of Retina and Vitreous·Ahmad MirshahiMojtaba Abrishami

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