PMID: 11314674Apr 21, 2001Paper

Effects of MK-801 and nicotine combinations on memory consolidation in CD1 mice

Psychopharmacology
A CiameiC Castellano

Abstract

Recent experiments have shown that pre-trial administrations of nicotine to rats tested in a 16-arm radial maze attenuated the MK-801-induced deficit in both working and reference memory performance. Memory consolidation can be influenced in laboratory animals, by post-training administration of drugs. In the present study we have investigated the effects on memory consolidation of CD1 mice exerted by: a) the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]cyclo-hepten-5, 10-imine-maleate] b) nicotine, and c) combinations of MK-801 and nicotine. Different groups of mice were injected intraperitoneally (IP) with the single drugs and with their combinations, immediately after training in a passive avoidance task. Additional groups of animals were also injected 2 h post-training with the highest effective dose of MK-801 (0.3 mg/kg), with the highest effective dose of nicotine (0.5 mg/kg) or with the combination of an otherwise ineffective dose of MK-801 (0.1 mg/kg) with the highest effective dose of nicotine, respectively. Their performances were compared with those of mice injected with saline, with the vehicle of nicotine and with the other treatment combinations...Continue Reading

Citations

Mar 20, 2003·Behavioural Brain Research·Gernot RiedelJacques Micheau
Apr 18, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A JacksonT Duka
Feb 12, 2011·Behavioural Brain Research·F Josef van der StaayArjan Blokland
Jun 10, 2015·Neuroscience and Biobehavioral Reviews·F Scott HallJared W Young
Aug 24, 2007·Biochemical Pharmacology·Ann Olincy, Karen E Stevens
Nov 14, 2006·Neuropharmacology·Jared W YoungJohn Sharkey
Feb 7, 2012·Annals of the New York Academy of Sciences·F Scott HallGeorge R Uhl
Mar 7, 2006·Trends in Neurosciences·Eran Meshorer, Hermona Soreq
Jan 7, 2006·The Journal of Pharmacology and Experimental Therapeutics·Tangui MauriceDaniel T Monaghan
May 12, 2021·Scientific Reports·Patrick M CallahanKyoko Koshibu

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