Effects of moderate hypoxia, hypercapnia and acidosis on haemodynamic changes induced by endothelin-1 in the pithed rat

British Journal of Pharmacology
M R MacLeanC R Hiley

Abstract

1. Pithed rats were respired at a fixed rate of 54 cycles min-1 and with a ventilation volume of either 20 (control) or 10 ml kg-1. In these two preparations, the dose-response relationships for the systemic blood pressure responses to endothelin-1, administered i.v., were examined. Also, cardiac output, its distribution, tissue blood flows and vascular resistances were determined at both respiratory volumes in pithed rats given saline or during pressor responses to endothelin-1 (750 ng, i.v.). Finally, a comparison was made of the pressor responses to endothelin-1 in the blood perfused superior mesenteric arterial bed of pithed rats respired at 10 or 20 ml kg-1. 2. In control rats the systemic blood pressure responses to i.v. endothelin-1 were biphasic with an initial, transient (30 s) decrease in blood pressure followed by a well sustained pressor response. These responses were dose-dependent (the ED50 for the pressor response being 0.27 +/- 0.04 micrograms). The pressor effect of endothelin-1 was due to an increase in total peripheral resistance with no change in heart rate or cardiac output. This increased total peripheral resistance was due to vasoconstriction of the spleen, stomach, large intestine, small intestine and th...Continue Reading

References

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Citations

Jul 1, 1992·Medicinal Research Reviews·T MasakiK Goto
Jul 18, 1989·European Journal of Pharmacology·P S LidburyJ R Vane
Nov 6, 1990·European Journal of Pharmacology·M R MacLean, J C McGrath
Jan 1, 1991·Pharmacology & Therapeutics·M D Randall
Jan 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·T W KrausC Herfarth
Dec 1, 1990·British Journal of Pharmacology·M D RandallT M Griffith
Feb 1, 1990·British Journal of Pharmacology·C ThiemermannJ R Vane
Jun 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A TorralboA Barrientos
Jun 6, 1998·The Journal of Surgical Research·M P LewisS W Ashley
Jan 1, 1994·Renal Failure·K S ChughK Joshi
May 18, 1999·The American Journal of Physiology·C E King-VanVlackC K Chapler
Mar 1, 1997·Renal Failure·M A BoimN Schor
Jul 4, 2003·Canadian Journal of Physiology and Pharmacology·Bruno Battistini
Mar 1, 1992·Metabolism: Clinical and Experimental·M RodenW Waldhäusl

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