Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice

Medical Gas Research
Yasuki HigashimuraYuji Naito

Abstract

Increasing evidence indicates that molecular hydrogen-dissolved alkaline electrolyzed water (AEW) has various physiological activities such as antioxidative activity. Gut microbiota are deeply associated with our health through a symbiotic relationship. Recent reports have described that most gastrointestinal microbial species encode the genetic capacity to metabolize molecular hydrogen, meaning that molecular hydrogen might affect the gut microbial composition. Nevertheless, AEW effects on gut microbiota remain unknown. This study investigated AEW effects on the intestinal environment in mice, including microbial composition and short-chain fatty acid contents. After mice were administered AEW for 4 weeks, 16S rRNA gene sequencing analyses revealed their fecal microbiota profiles. Organic acid concentrations in cecal contents were measured using an HPLC system. Compared to the control group, AEW administration mice had significantly lower serum low-density lipoprotein cholesterol level and alanine aminotransferase activity. Organic acid concentrations of propionic, isobutyric, and isovaleric acids were higher in AEW-administered mice. Results of 16S rRNA gene sequencing analyses showed that the relative abundances of 20 taxa d...Continue Reading

Citations

Jul 15, 2018·Applied and Environmental Microbiology·Lingyu YangHe Meng
Dec 13, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Takaaki YahiroMasafumi Inomata
Sep 24, 2020·Oxidative Medicine and Cellular Longevity·Mengling YangMingyi Zhao
Aug 9, 2018·Journal of Clinical Biochemistry and Nutrition·Yuji NaitoTomohisa Takagi
Jan 14, 2021·Microorganisms·Pianpian YanDeog-Hwan Oh
Dec 15, 2020·Current Pharmaceutical Design·Svetlana N Radyuk

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Methods Mentioned

BETA
PCR

Software Mentioned

GraphPad Prism
BLAST
Usearch
Clean Fastq
QIIME
Quantitative insights into Microbial Ecology ( QIIME ) pipeline

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