PMID: 11337150May 5, 2001Paper

Effects of molecular weight of polyvinylpyrrolidone on the glass transition and crystallization of co-lyophilized sucrose

International Journal of Pharmaceutics
X M ZengC Marriott

Abstract

The purpose of the present study was to investigate the effects of molecular weight (MW) of polyvinylpyrrolidone (PVP) on glass transition and crystallization of sucrose. Thus, sucrose was co-lyophilized with 2.5 and 5.0% w/w PVP of different molecular weights, which were characterized using gel permeation chromatography. Freeze drying was carried out for 48 h at a shelf temperature of -40 degrees C and a pressure of about 36 Pa. The samples were then dried in a vacuum oven at 24 degrees C for 12 h before drying for a further 12 h at 40 degrees C. Differential scanning calorimetry (DSC) was employed to measure the glass transition temperature (Tg), dynamic crystallization temperature (Tc) and isothermal crystallization induction time (tc) at 85 degrees C of sucrose. Isothermal water vapour sorption of each sample was also measured at different relative humidities. Tg values of sucrose varied from 48.3+/-0.8 degrees C for freeze-dried (FD) sucrose alone to 58.8+/-0.8 degrees C for the mixture containing 5.0% PVP of nominal MW 300 K. PVP increased sucrose T(g) significantly (ANOVA P<0.05). Although there was no significant difference (P>0.05) in Tg of the mixtures containing 2.5% w/w PVP of different MW, samples with 5.0% PVP of ...Continue Reading

Citations

Feb 6, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jonas Berggren, Göran Alderborn
Dec 31, 2011·Journal of the American Chemical Society·Xiaohu XiaYounan Xia
Feb 8, 2006·Applied and Environmental Microbiology·Frédéric DumontPatrick Gervais
Jan 18, 2006·AAPS PharmSciTech·Dongmei Lu, Anthony J Hickey
Aug 2, 2006·Chemical & Pharmaceutical Bulletin·Tamaki MiyazakiYukio Aso
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