Effects of moniliformin in presence of cyclohexadepsipeptides on isolated mammalian tissue and cells

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Majid-Reza KamyarRosa Lemmens-Gruber

Abstract

Secondary metabolites produced by Fusarium spp. including beauvericin, enniatin and moniliformin are mycotoxins identified in cereal samples. The two cyclohexadepsipeptide mycotoxins beauvericin and enniatin have cytotoxic, antibiotic, insecticidal and ionophoric properties, while moniliformin primarily acts as a cardiotoxic mycotoxin. In this study, we examined the electromechanical and electrophysiological effects of moniliformin and moniliformin with ionophoric mycotoxins on cells (ventricular myocytes, Caco-2 cells) and in multicellular preparations (papillary muscles and terminal ilea of the guinea pig). Additionally, we investigated the influence of moniliformin on cell homeostasis in absence and presence of the cyclodepsipeptide mycotoxins (ventricular myocytes, Caco-2 cells). Experiments were performed using isometric measurements of contractility, intracellular microelectrode and patch-clamp techniques, and fluorescence imaging. While ionophoric cyclohexadepsipeptides affect action potential parameters and cell homeostasis, moniliformin did not change spontaneous rates of activity or cardiac action potentials. Furthermore, moniliformin had no effect on intracellular concentrations of ions and ATP, and did not affect pH...Continue Reading

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Citations

Sep 1, 2007·International Journal of Food Microbiology·Franz BerthillerRainer Schuhmacher
Jun 12, 2009·Molecular Nutrition & Food Research·Rita DornetshuberWalter Berger
May 12, 2009·Biochemical Pharmacology·R DornetshuberR Lemmens-Gruber
Apr 22, 2015·Critical Reviews in Food Science and Nutrition·Bregje Van De WierGuido R M M Haenen
Dec 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Martina JonssonKimmo Peltonen
Sep 8, 2016·Journal of Agricultural and Food Chemistry·Christiane Gruber-DorningerFranz Berthiller
Aug 2, 2014·Molecular Cancer Therapeutics·Ute JungwirthWalter Berger
Jan 21, 2021·Toxins·Ludmila KřížováTomáš Kašparovský

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