PMID: 2506486Aug 1, 1989Paper

Effects of monoamine oxidase inhibitors on levels of catechols and homovanillic acid in striatum and plasma

Neuropharmacology
D Hovevey-SionD S Goldstein

Abstract

Levels of homovanillic acid (HVA), dihydroxyphenylacetic acid (DOPAC) and dihydroxyphenylglycol (DHPG) in plasma and the striatium were measured after inhibition of monoamine oxidase type A (MAO-A) by clorgyline (4 mg/kg i.p.), MAO-B by (-)deprenyl (1 mg/kg i.p.), both MAO-A and MAO-B by nialamide (75 mg/kg i.p.) or peripheral neuronal MAO by debrisoquin (40 mg/kg i.p.). Levels of HVA in plasma decreased by about 60% after single doses of nialamide or clorgyline, by about 80% after repeated doses of nialamide, by about 40% after a single dose of debrisoquin and by about 50% after repeated doses of debrisoquin. The administration of clorgyline, nialamide or debrisoquin significantly decreased concentrations of DOPAC and DHPG in plasma, whereas (-)deprenyl did not affect levels of DHPG or HVA. None of the MAO inhibitors produced more than about 80% depression of levels of any of the deaminated metabolites. The results suggest that most of the HVA in plasma is derived from deamination of DA by MAO-A in peripheral neurons; that DOPAC in plasma is derived from cells outside the central nervous system; that DHPG in plasma is derived virtually exclusively from the metabolism of norepinephrine in sympathetic nerve endings and that resi...Continue Reading

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Citations

Jul 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·J LyytinenH Teräväinen
Jan 1, 1993·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·E H HeinonenM Scheinin
Jul 14, 2010·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·David S Goldstein
Mar 21, 1994·European Journal of Pharmacology·A V JuorioM Y Zhu
Mar 1, 1996·Journal of the Neurological Sciences·J E AhlskogE Kokmen
Jan 1, 1991·Acta Neurologica Scandinavica. Supplementum·E H Heinonen, R Lammintausta
Dec 29, 1995·Annals of the New York Academy of Sciences·D S Goldstein
Jul 23, 2002·Biological & Pharmaceutical Bulletin·Naoki HarikaiShin-ichi Tashiro
Nov 18, 2015·The Journal of Pharmacology and Experimental Therapeutics·David S GoldsteinYehonatan Sharabi

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