PMID: 9421829Jan 9, 1998Paper

Effects of monosialoganglioside on a new model of tardive dyskinesia

Progress in Neuro-psychopharmacology & Biological Psychiatry
M A VitalJ Palermo-Neto

Abstract

1- The effects of monosialoganglioside GM1 were studied on a new model of tardive dyskinesia, i.e., the frequency of spontaneous tongue protrusions in rats repeatedly treated with reserpine. 2- Rats were co-treated with vehicle (VEH) or reserpine (RES) (0.1 mg/kg, s.c., every other day) and saline (SAL) or GM1 (5 mg/kg, i.p., every day) for 30 days and observed for tongue protrusions on days 10, 20 and 30. 3- During each test day animals of the RES + SAL group exhibited an increase in tongue protrusions relative to rats of the VEH + SAL group. However, rats of the RES + GM1 group showed an increased frequency of tongue protrusions only on day 10, when compared to animals of the VEH + SAL group. There were no significant differences in tongue protrusion frequency between the VEH + GM1 and the VEH + SAL groups. 4- These results differ from previous studies which reported a facilitatory effect of GM1 co-administration on conventional behavioral animal models of tardive dyskinesia. The possibility is raised that GM1 attenuates the reserpine-induced increase in tongue protrusions through its protective effect on glutamate/oxidative stress neurotoxicity.

References

Sep 3, 1979·Life Sciences·C RolstenT Samorajski
Jun 1, 1992·The American Journal of Psychiatry·M F EganR J Wyatt
Dec 1, 1991·Archives of General Psychiatry·J B Lohr
Apr 1, 1990·The American Journal of Psychiatry·A M ElkashefD Barrett
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Wolfarth, K Ossowska
Apr 18, 1987·Lancet·J B LohrR J Wyatt
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M FavaronE Costa
May 10, 1988·European Journal of Pharmacology·R Frussa-Filho, J Palermo-Neto
Jan 1, 1987·Physiology & Behavior·L F FelicioJ Palermo-Neto
Jan 1, 1973·The American Journal of Psychiatry·H L Klawans
Oct 1, 1972·Archives of General Psychiatry·R Rubovits, H L Klawans
Dec 3, 1982·European Journal of Pharmacology·C H MisraR C Smith
Jul 1, 1993·Journal of Cardiovascular Pharmacology·N MaulikN Denisova
Jan 1, 1995·Life Sciences·M A VitalJ Palermo-Neto
Oct 29, 1993·Science·J T Coyle, P Puttfarcken
May 1, 1993·Journal of Pineal Research·B PoeggelerL C Manchester
Sep 1, 1993·The American Journal of Psychiatry·L A AdlerB Angrist
Dec 1, 1995·Psychiatry and Clinical Neurosciences·T Inada, G Yagi

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Citations

Jun 15, 2005·Pharmacology, Biochemistry, and Behavior·Marilise E BurgerJoão B T Rocha
Oct 17, 1998·European Journal of Pharmacology·C M QueirozR Frussa-Filho
May 9, 2002·Behavioural Brain Research·Regina H SilvaRoberto Frussa-Filho
Feb 2, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Patricia R V CalventeFilho Roberto Frussa
May 10, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Renata C DutraMaria A B F Vital
Jan 29, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Vanessa C AbílioRoberto Frussa-Filho
Jan 29, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marilise E BurgerJoão B T Rocha
Jan 13, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·C M Queiroz, R Frussa-Filho
Apr 3, 1999·General Pharmacology·J Palermo-NetoM A Vital
Feb 5, 2003·The International Journal of Biochemistry & Cell Biology·Michele Rechia FigheraCarlos Fernando Mello
Nov 25, 2004·Brain Research Bulletin·Marilise BurgerJoão B T Rocha
Aug 6, 2004·Free Radical Research·Michele Rechia FigheraCarlos Fernando Mello

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