Effects of morning hypoglycemia on neuroendocrine and metabolic responses to subsequent afternoon hypoglycemia in normal man

The Journal of Clinical Endocrinology and Metabolism
S N Davis, D Tate

Abstract

There is general agreement that prior hypoglycemia blunts subsequent hypoglycemic counterregulatory responses. However, there is considerable debate concerning the timing and number of prior hypoglycemic episodes required to cause this blunting effect. The aim of this study was to determine whether one episode of hypoglycemia could modify neuroendocrine, metabolic, and symptom responses to hypoglycemia induced 2 h later. A total of 24 (12 male and 12 female) young, healthy, overnight-fasted subjects participated in a series of glucose clamp studies. A total of 16 individuals underwent 2 randomized studies of either identical 2-h morning and afternoon hyperinsulinemic (490 +/- 60 pmol/L) hypoglycemia (2.9 +/- 0.1 mmol/L) separated by 2 h or, at least 2 months later, 2-h morning and afternoon hyperinsulinemic (492 +/- 45 pmol/L) euglycemia (5.1 +/- 0.1 mmol/L). A total of 8 other subjects participated in a single experiment that consisted of 2-h morning hyperinsulinemic (516 +/- 60 pmol/L) euglycemia (5.1 +/- 0.1 mmol/L) and 2-h afternoon hyperinsulinemic (528 +/- 66 pmol/L) hypoglycemia (2.9 +/- 0.1 mmol/L) also separated by 2 h. Morning hypoglycemia significantly (P < 0.01) reduced (33-55%) the responses of epinephrine, norepin...Continue Reading

References

Sep 1, 1978·The Journal of Clinical Investigation·A D CherringtonJ L Chiasson
Dec 1, 1992·Diabetes·B Widom, D C Simonson
Nov 1, 1991·The Journal of Clinical Endocrinology and Metabolism·M R Davis, H Shamoon
Jun 1, 1991·The Journal of Clinical Investigation·E A AndersonA L Mark
Jun 1, 1989·The Journal of Clinical Endocrinology and Metabolism·D KerrR B Tattersall
Aug 1, 1987·The Journal of Clinical Investigation·S AttvallU Smith
May 28, 1987·The New England Journal of Medicine·S A AmielR S Sherwin
May 1, 1974·The Journal of Clinical Investigation·R S SherwinR Andres
Jun 1, 1969·The American Journal of the Medical Sciences·E Aguilar-ParadaR H Unger
Jul 1, 1970·Analytical Biochemistry·R J Ho
Aug 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·K N Frayn
Sep 1, 1981·Analytical Biochemistry·R C CausonR Rodnight
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·P J BoyleC Qualls
Feb 1, 1993·Diabetes Care·D J CoxW L Clarke
Aug 1, 1996·The Journal of Clinical Investigation·S N DavisR Mosqueda-Garcia

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Citations

Jul 2, 2009·The Journal of Clinical Endocrinology and Metabolism·James LeuIlan Gabriely

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