Effects of morphine, hypoxaemia and hypercapnia on the rat stomach

European Journal of Pharmacology
M M HoS Dai

Abstract

The effects of morphine, hypoxaemia or hypercapnia on gastric acid secretion, gastric mucus synthesis and the gastric mucosa were studied in conscious rats with pyloric occlusion. Hypoxaemia and hypercapnia were induced by morphine 32 mg/kg given i.p., or each condition was produced separately by adjusting the composition of respired air in the chamber where the animals were kept during the experimental period. Hypoxia significantly enhanced gastric mucus synthesis whereas hypercapnia significantly reduced gastric acid secretion. These effects were significantly alleviated by atropine pretreatment. Morphine-treated rats exhibited decreased gastric acid secretion, increased gastric mucus synthesis and a higher mean ulcer index but only the reduced gastric acid output was significantly prevented by atropine. It is suggested that the effect of morphine on gastric acid secretion may result from its respiratory depressant action and consequent acute stress production. However, the mechanisms by which morphine can increase mucus synthesis and produce ulceration remain obscure.

References

Sep 1, 1985·Pharmacological Research Communications·M M HoS Dai
Mar 11, 1986·European Journal of Pharmacology·M M HoS Dai
Jan 1, 1972·Pflügers Archiv : European journal of physiology·S Dai, C W Ogle
Apr 1, 1974·European Journal of Pharmacology·S Dai, C W Ogle
Jun 15, 1984·European Journal of Pharmacology·M M HoC W Ogle
Jan 1, 1982·Biochemical Pharmacology·G E Gibson, C Peterson
Aug 1, 1982·Scandinavian Journal of Gastroenterology·B K Semb

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Citations

Jan 10, 1991·European Journal of Pharmacology·K Tazi-SaadC Rozé
May 1, 1992·British Journal of Pharmacology·J V EspluguesJ Esplugues

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