Effects of morphine on the experimental illusion of pain produced by a thermal grill

Pain
Delphine KernDidier Bouhassira

Abstract

We compared the effects of systemic morphine on normal (heat and cold) pain and paradoxical burning pain evoked by the simultaneous application of innocuous warm and cold stimuli to the skin. Twelve healthy volunteers participated in a randomised, double-blind, cross-over study to compare the effects of intravenous administration of morphine (0.025 or 0.1mg/kg) or placebo (saline). Stimuli were applied to the palm of the right hand with a thermode ("thermal grill") composed of six bars, whose temperatures were controlled by Peltier elements. For each session, we measured the heat and cold pain thresholds and then successively measured the intensity of: (i) paradoxical pain evoked by a combination of non-noxious warm and cold stimuli; (ii) "normal" pain evoked by suprathreshold heat or cold stimuli; (iii) non-painful sensations evoked by warm or cold stimuli at temperatures used to produce paradoxical pain. Measurements were performed before 20min after the administration of morphine or placebo and 5min after the administration of the morphine antagonist, naloxone. The administration of 0.1mg/kg of morphine, but not 0.025mg/kg, induced a significant and naloxone-reversible reduction of paradoxical pain intensity, which was direc...Continue Reading

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Citations

Nov 19, 2011·PloS One·Fredrik LindstedtMartin Ingvar
Jan 1, 2011·Pain Management·Laxmaiah ManchikantiStandiford Helm
Feb 13, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Nicole M SumrackiPaul Rolan
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Dec 8, 2014·The Journal of Pain : Official Journal of the American Pain Society·Andrew McKeownShannon M Smith
Jan 13, 2017·Scientific Reports·Catherine R JutzelerJohn L K Kramer
Jun 3, 2017·European Journal of Pain : EJP·D E Harper, M Hollins
Nov 20, 2016·British Journal of Clinical Pharmacology·Pieter OkkerseGeert Jan Groeneveld
Apr 29, 2015·European Journal of Pain : EJP·P AlfonsiD Bouhassira
Aug 18, 2020·Neurobiology of Disease·Julia ForstenpointnerDavid Borsook
Aug 28, 2021·Journal of Clinical Medicine·Dong Ah Shin, Min Cheol Chang

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